Diagnostic method of Helicobacter heilmannii infection based on genetic analysis

基于基因分析的海尔曼螺杆菌感染诊断方法

• 批准号: 22790136
• 负责人: MIKI Ikuya
• 金额: $ 2.66万
• 依托单位: Kobe Pharmaceutical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22790136/
• 关键词: ヘリコバクターハイルマニ; ウレアーゼ

Helicobacter heilmannii infection is possibly associated with gastric MALT lymphoma in mice model and human, and however, its diagnostic method has not been established yet. In this study, we succeed in the diagnosis of its infection with gastric mucosa by analyzing pathogenic genes of H. pylori and H. heilmannii. In the next step, we tried to establish the serodiagnosis using monoclonal antibody, but our antibody showed cross-reactivity. Therefore, we are going on analyzing the other virulent genes.

海氏螺杆菌感染可能与小鼠模型和人类胃MALT淋巴瘤有关，但其诊断方法尚未建立。本研究通过分析H. pylori和H.海尔曼尼。在下一步中，我们尝试使用单克隆抗体建立血清学诊断，但我们的抗体显示交叉反应性。因此，我们将继续分析其他毒性基因。

项目成果

Neonatal Fc receptor for IgG (FcRn) expressed in the gastric epithelium regulates bacterial infection in mice.

• DOI: 10.1038/mi.2011.53
• 发表时间: 2012-01
• 期刊: Mucosal immunology
• 影响因子: 8

IFN-γ plays an essential role in the pathogenesis of gastric lymphoid follicles formation caused by Helicobacter suis infection

• DOI: 10.1111/j.1574-695x.2011.00823.x
• 发表时间: 2011-10-01
• 期刊: FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY
• 作者: Mimura, Takuya;Yoshida, Masaru;Azuma, Takeshi
• 通讯作者: Azuma, Takeshi

Helicobacter suis KB1 derived from pig gastric lymphoid follicles induces the formation of gastric lymphoid follicles in mice through the activation of B cells and CD4 positive cells

• DOI: 10.1016/j.micinf.2011.02.007
• 发表时间: 2011-07-01
• 期刊: MICROBES AND INFECTION
• 影响因子: 5.8
• 作者: Yamamoto, Koji;Tanaka, Hiroshi;Azuma, Takeshi
• 通讯作者: Azuma, Takeshi