Functional analysis of Trem-like 4 in mice

Trem-like 4在小鼠体内的功能分析

• 批准号: 22790376
• 负责人: HEMMI Hiroaki
• 金额: $ 2.5万
• 依托单位: Osaka University (2011)The Institute of Physical and Chemical Research (2010)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22790376/
• 关键词: 樹状細胞; マクロファージ; イムノグロブリンスーパーファミリー; サブセット; 受容体

Triggering Receptor Expressed on Myeloid cells(Trem) family is characterized by an immunoglobulin-like domain at extracellular domain and short cytoplasmic tail. In this study, we aimed to clarify physiological functions of a Trem family member, Trem-like 4(Treml4). We could found a candidate molecule of Treml4 ligand. In addition, we analyzed Treml4-deficent mice. In Treml4-deficient mice, uptake of dying cells and cross-presentation of cell-associated antigens in vivo was similarly observed to that in littermate control mice, suggesting that Treml4 is not involved in these responses. We also found that an engineered anti-Treml4 antibody conjugated with antigens can efficiently induce T cell responses.

髓系细胞触发受体（Trem）家族具有胞外免疫球蛋白样结构域和短胞浆尾的特征。在这项研究中，我们旨在阐明Trem家族成员Trem-like 4（trem14）的生理功能。我们可以找到一个候选的Treml4配体分子。此外，我们分析了trem14缺陷小鼠。在缺乏Treml4的小鼠中，在体内观察到死亡细胞的摄取和细胞相关抗原的交叉呈递与同窝对照小鼠相似，表明Treml4不参与这些反应。我们还发现与抗原结合的工程化抗treml4抗体可以有效地诱导T细胞反应。

项目成果

ケモカイン受容体Xcr1発現樹状細胞のin vivoにおける機能的意義

表达趋化因子受体Xcr1的树突状细胞的体内功能意义

• 发表时间: 2011
• 作者: 高木豪;石井俊輔;高木豪;伊藤量基;山崎千尋;山崎千尋
• 通讯作者: 山崎千尋

Conservation of a chemokine system, XCR1 and its ligand, XCL1, between human and mice

• DOI: 10.1016/j.bbrc.2010.06.029
• 发表时间: 2010-07-09
• 期刊: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
• 影响因子: 3.1
• 作者: Yamazaki, Chihiro;Miyamoto, Rie;Kaisho, Tsuneyasu
• 通讯作者: Kaisho, Tsuneyasu

Treml4, an Ig superfamily member, mediates presentation of several antigens to T cells in vivo, including protective immunity to HER2 protein.

• DOI: 10.4049/jimmunol.1102541
• 发表时间: 2012-02-01
• 期刊: Journal of immunology (Baltimore, Md. : 1950)
• 作者: Hemmi H;Zaidi N;Wang B;Matos I;Fiorese C;Lubkin A;Zbytnuik L;Suda K;Zhang K;Noda M;Kaisho T;Steinman RM;Idoyaga J
• 通讯作者: Idoyaga J

CD8 陽性樹状細胞サブセットの動的制御機構の解析

CD8阳性树突状细胞亚群动态调控机制分析

• 发表时间: 2012
• 期刊: Cytometry Research
• 作者: 辺見弘明;山崎千尋; 星野克明;改正恒康
• 通讯作者: 改正恒康

CD8陽性樹状細胞の動的制御機構の解析

CD8阳性树突状细胞的动态调控机制分析

• 发表时间: 2011
• 作者: 邊見弘明;山崎千尋;星野克明;改正恒康
• 通讯作者: 改正恒康