Functional analysis of Trem-like 4 in mice

髓样细胞表达的触发受体（Trem）家族的特征在于细胞外结构域处的免疫球蛋白样结构域和短的胞质尾。在这项研究中，我们的目的是阐明Trem家族成员Trem-like 4（Treml4）的生理功能。我们可以找到一个Trem14配体的候选分子。此外，我们分析了Treml4缺陷小鼠。在Treml4缺陷型小鼠中，与同窝对照小鼠中类似地观察到死亡细胞的摄取和细胞相关抗原的体内交叉呈递，表明Treml4不参与这些应答。我们还发现与抗原缀合的工程化抗Treml4抗体可以有效地诱导T细胞应答。

Triggering Receptor Expressed on Myeloid cells(Trem) family is characterized by an immunoglobulin-like domain at extracellular domain and short cytoplasmic tail. In this study, we aimed to clarify physiological functions of a Trem family member, Trem-like 4(Treml4). We could found a candidate molecule of Treml4 ligand. In addition, we analyzed Treml4-deficent mice. In Treml4-deficient mice, uptake of dying cells and cross-presentation of cell-associated antigens in vivo was similarly observed to that in littermate control mice, suggesting that Treml4 is not involved in these responses. We also found that an engineered anti-Treml4 antibody conjugated with antigens can efficiently induce T cell responses.