Functional analysis of a new Trem molecule

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Triggering receptor expressed on myeloid cells (Trem) family is known to regulate activation status of immune cells. In this study, we tried to uncover the function of a newly identified Trem molecule. It has been reported that the expression levels of other Trem members are up-regulated or down-regulated when the cells were activated. However, the expression of this molecule on dendritic cells (DCs) was not altered after their activation. In addition, the results from analyses of gene-knocked out mice suggest that this molecule is not involved in uptake of apoptotic cells by DCs. On the other hand, gene knocked-out mice showed slightly enhanced responses in terms of cytokine productions and antibody induced arthritis, suggesting that this molecule may be negatively involved in inflammatory responses.