Role of Lipocalin 2 during malaria infection

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Malaria is one of the most deadly infectious diseases in the world, with no effective vaccine yet that many of the host immune responses against malaria parasites remain unclear. Plasmodium parasites feed and multiply within erythrocytes, and their egress from these cells results in various degrees of anemia. Little is known about how host iron homeostasis affects the immune system during malaria. In this research we found that Lipocalin 2, a known early innate immune response molecule, is abundantly secreted during mouse malaria infection, and is required for the clearance of parasites. Therefore, results of this research may lead to a new understanding of Lcn2-mediated anti-malarial immunity through the modulation of host iron metabolism.