Serologic markers in relation to parasite exposure history help to estimate transmission dynamics of Plasmodium vivax.
Serologic markers in relation to parasite exposure history help to estimate transmission dynamics of Plasmodium vivax.
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DOI：
10.1371/journal.pone.0028126
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发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Coban C
中科院分区：
文献类型：
--
作者：
Yildiz Zeyrek F;Palacpac N;Yuksel F;Yagi M;Honjo K;Fujita Y;Arisue N;Takeo S;Tanabe K;Horii T;Tsuboi T;Ishii KJ;Coban C
间日疟原虫感染因其在世界多个地区重新出现而受到关注。土耳其东南部是发生完全由间日疟原虫寄生虫引起的持续性局灶性疟疾的地方之一。虽然控制和消除研究已经进行了很多年，但还没有进行详细的研究来了解该地区疟疾控制无效的机制。在这里，我们首次使用血清学标记，试图在该地区提取尽可能多的信息，以了解间日疟原虫的传播。我们进行了一项血清免疫学研究，评价生活在桑柳尔法的个体对四种不同间日疟原虫抗原的抗体应答;三种血液阶段抗原（PvMSP 119、PvAMA 1-ecto和PvSERA 4）和一种红细胞前期抗原（PvCSP）。结果表明，先前的疟疾感染史和年龄可能是自然获得抗体的水平和可持续性的决定因素。在有疟疾感染史的血涂片阴性个体中观察到对所有研究抗原的显着较高的抗体应答。此外，这些人明显比没有感染史的血涂片阴性的人年龄大。这些数据可能对全球疟疾控制/消除计划和疫苗设计具有重要意义。
Plasmodium vivax infection has been gaining attention because of its re-emergence in several parts of the world. Southeastern Turkey is one of the places in which persistent focal malaria caused exclusively by P. vivax parasites occurs. Although control and elimination studies have been underway for many years, no detailed study has been conducted to understand the mechanisms underlying the ineffective control of malaria in this region. Here, for the first time, using serologic markers we try to extract as much information as possible in this region to get a glimpse of P. vivax transmission. We conducted a sero-immunological study, evaluating antibody responses of individuals living in Sanliurfa to four different P. vivax antigens; three blood-stage antigens (PvMSP119, PvAMA1-ecto, and PvSERA4) and one pre-erythrocytic stage antigen (PvCSP). The results suggest that a prior history of malaria infection and age can be determining factors for the levels and sustainability of naturally acquired antibodies. Significantly higher antibody responses to all the studied antigens were observed in blood smear-negative individuals with a prior history of malaria infection. Moreover, these individuals were significantly older than blood smear-negative individuals with no prior history of infection. These data from an area of sole P. vivax-endemic region may have important implications for the global malaria control/elimination programs and vaccine design.
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DOI：
10.1093/cid/ciq249
发表时间：
2011-03-01
期刊：
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
影响因子：
--
作者：
Douglas NM;Nosten F;Ashley EA;Phaiphun L;van Vugt M;Singhasivanon P;White NJ;Price RN
通讯作者：
Price RN
影响因子：
3.7
作者：
Lin JT;Bethell D;Tyner SD;Lon C;Shah NK;Saunders DL;Sriwichai S;Khemawoot P;Kuntawunggin W;Smith BL;Noedl H;Schaecher K;Socheat D;Se Y;Meshnick SR;Fukuda MM
通讯作者：
Fukuda MM
影响因子：
6.4
作者：
Imwong, Mallika;Snounou, Georges;White, Nicholas J.
通讯作者：
White, Nicholas J.
DOI：
10.4269/ajtmh.2010.09-0633
发表时间：
2010-11-01
影响因子：
3.3
作者：
Kochar, Dhanpat Kumar;Tanwar, Gajanand Singh;Das, Ashish
通讯作者：
Das, Ashish
DOI：
10.4269/ajtmh.2001.64.97
发表时间：
2001-01-01
影响因子：
3.3
作者：
Mendis, K;Sina, BJ;Carter, R
通讯作者：
Carter, R