Limited polymorphism of the Plasmodium vivax merozoite surface protein 1 gene in isolates from Turkey.
Limited polymorphism of the Plasmodium vivax merozoite surface protein 1 gene in isolates from Turkey.
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土耳其分离株间日疟原虫裂殖子表面蛋白 1 基因的有限多态性。
DOI：
10.4269/ajtmh.2010.10-0353
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
K. Tanabe
中科院分区：
文献类型：
--
作者：
F. Zeyrek;Shin;F. Yuksel;N. Doni;N. Palacpac;N. Arisue;T. Horii;C. Coban;K. Tanabe
间日疟原虫裂殖子表面蛋白（PvMSP-1）是间日疟原虫疟疾的主要候选疫苗之一。然而，编码PvMSP-1（pvmsp 1）的基因具有高度多态性，是有效疫苗开发的主要障碍。为了进一步了解pvmsp 1的多态性，我们从土耳其东南部获得了30个全长pvmsp 1序列。从土耳其和其他地区的序列的比较分析表明，基本上有限的多态性。在其他地区和土耳其的样品中，分别在280和162个氨基酸位点处发现了取代。8次换人是土耳其独有的。在其中一个，D/E在位置1706在C-末端19-kD区域，K/E的变化在1709是唯一的多态性先前已知的。在微卫星中也观察到有限的多样性。数据表明，最近在土耳其的人口瓶颈，可能掩盖了平衡选择的C-末端42-kD区域，这是在其他地区检测到的签名。
The 200-kD merozoite surface protein of Plasmodium vivax (PvMSP-1) is one of the leading vaccine candidates against P. vivax malaria. However, the gene encoding PvMSP-1 (pvmsp1) is highly polymorphic and is a major obstacle to effective vaccine development. To further understand polymorphism in pvmsp1, we obtained 30 full-length pvmsp1 sequences from southeastern Turkey. Comparative analysis of sequences from Turkey and other areas showed substantially limited polymorphism. Substitutions were found at 280 and 162 amino acid sites in samples from other regions and those from Turkey, respectively. Eight substitutions were unique to Turkey. In one of them, D/E at position 1706 in the C-terminal 19-kD region, the K/E change at 1709 was the only polymorphism previously known. Limited diversity was also observed in microsatellites. Data suggest a recent population bottleneck in Turkey that may have obscured a signature for balancing selection in the C-terminal 42-kD region, which was otherwise detectable in other areas.
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