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Molecular characterization of novel isoniazid resistance mechanism in Mycobacterium tuberculosis

Molecular characterization of novel isoniazid resistance mechanism in Mycobacterium tuberculosis
结核分枝杆菌新型异烟肼耐药机制的分子表征
批准号:
22790423
负责人:
ANDO Hiroki
金额:
$2.5万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2011

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中文摘要
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英文摘要
Novel isoniazid (INH) resistance mutations were identified and characterized in Mycobacterium tuberculosis (Mtb). I collected INH-resistant Mtb clinical isolates and found that many of them have no mutations in known INH resistance genes. I identified several novel mutations in these isolates, and analyzed their roles in INH resistance.
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Mutations in the furA-katG intergenic region decrease katG expression and confer isoniazid resistance in Mycobacterium tuberculosis
FurA-katG 基因间区域的突变降低了 katG 表达并赋予结核分枝杆菌异烟肼耐药性
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [Ando H, Kitao T, Miyoshi-Akiyama T, Kato S, Mori T Kirikae T.]
通讯作者: Mori T Kirikae T.
結核菌のfabG1 遺伝子内サイレント変異によるイソニアジド耐性機序の解明
结核分枝杆菌fabG1基因沉默突变阐明异烟肼耐药机制
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [安藤弘樹, 加藤誠也, 森亨, 切替照雄]
通讯作者: 切替照雄
DOI: 10.1111/j.1365-2958.2011.07547.x
发表时间: 2011-03-01
期刊: MOLECULAR MICROBIOLOGY
影响因子: 3.6
作者: [Ando, Hiroki, Kitao, Tomoe, Kirikae, Teruo]
通讯作者: Kirikae, Teruo
Evaluation of a line probe assay for rapid detection of gyrA mutations associated with fluoroquinolone resistance in multidrug-resistant Mycobacterium tuberculosis.
评估用于快速检测多重耐药结核分枝杆菌中与氟喹诺酮耐药性相关的 gyrA 突变的线性探针测定。
DOI: --
发表时间: 2011
期刊: J.Med.Microbiol
影响因子: --
作者: [Ando H., Mitarai S., Kondo Y., Suetake T., Kato S., Mori T., Kirikae T.]
通讯作者: Kirikae T.
8
    Creation of Synthetic Bacteriophages -Treatment of Drug-Resistant Bacterial Infections and Human Microbiota Editing-
    • 批准号:
      15K21770
    • 项目类别:
      Fund for the Promotion of Joint International Research (Home-Returning Researcher Development Research)
    • 资助金额:
      $36.61万
    • 财政年份:
      2017
    • 负责人:
      ANDO Hiroki
    • 依托单位:
    Venusian thermal tides investigated by radio occultation measurement
    • 批准号:
      25887056
    • 项目类别:
      Grant-in-Aid for Research Activity Start-up
    • 资助金额:
      $1.66万
    • 财政年份:
      2013
    • 负责人:
      ANDO Hiroki
    • 依托单位:
    High functionalization of an elastic finger gripper by passive control of elastic large deformation
    • 批准号:
      25820084
    • 项目类别:
      Grant-in-Aid for Young Scientists (B)
    • 资助金额:
      $2.75万
    • 财政年份:
      2013
    • 负责人:
      ANDO Hiroki
    • 依托单位:
    Study on flexible gripping mechanism for realizing miniature electric gripper
    • 批准号:
      20760164
    • 项目类别:
      Grant-in-Aid for Young Scientists (B)
    • 资助金额:
      $2.83万
    • 财政年份:
      2008
    • 负责人:
      ANDO Hiroki
    • 依托单位:
    海外基金