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The association between blood polyphenol levels and DNA methylation levels in gastric mucosa

The association between blood polyphenol levels and DNA methylation levels in gastric mucosa
血多酚水平与胃粘膜DNA甲基化水平的关系
批准号:
22790554
负责人:
SHIMAZU Taichi
金额:
$2.16万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2011

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中文摘要
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英文摘要
We conducted a cross-sectional study to investigate the association between blood polyphenol levels and DNA methylation levels in gastric mucosa of participants(n=300) who underwent upper gastrointestinal endoscopy as part of the cancer screening program. We found no association between serum polyohenol levels(daidzein, genistein,(-)-epicatechin,(-)-epicatechin-3-gallate,(-)-epigallocatechin, and(-)-epigallocatechin-3-gallate) and DNA methylation levels of three markers which were associated with gastric cancer risk.
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DOI: 10.1016/j.ygeno.2011.06.003
发表时间: 2011-09
期刊: Genomics
影响因子: 4.4
作者: [Hideyuki Takeshima;S. Yamashita;T. Shimazu;T. Ushijima]
通讯作者: Hideyuki Takeshima;S. Yamashita;T. Shimazu;T. Ushijima
DOI: 10.3945/ajcn.111.020479
发表时间: 2012-01-01
期刊: AMERICAN JOURNAL OF CLINICAL NUTRITION
影响因子: 7.1
作者: [Hara, Azusa, Sasazuki, Shizuka, Tsugane, Shoichiro]
通讯作者: Tsugane, Shoichiro
Nested case-control study to clarify a preventive factor of lung cancer.
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