The association between blood polyphenol levels and DNA methylation levels in gastric mucosa

血多酚水平与胃粘膜DNA甲基化水平的关系

• 批准号: 22790554
• 负责人: SHIMAZU Taichi
• 金额: $ 2.16万
• 依托单位: National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22790554/
• 关键词: エピジェネティクス; 胃がん; 食事; 疫学

We conducted a cross-sectional study to investigate the association between blood polyphenol levels and DNA methylation levels in gastric mucosa of participants(n=300) who underwent upper gastrointestinal endoscopy as part of the cancer screening program. We found no association between serum polyohenol levels(daidzein, genistein,(-)-epicatechin,(-)-epicatechin-3-gallate,(-)-epigallocatechin, and(-)-epigallocatechin-3-gallate) and DNA methylation levels of three markers which were associated with gastric cancer risk.

我们进行了一项横断面研究，以调查参与者（n=300）接受上消化道内窥镜检查作为癌症筛查计划的一部分，血液多酚水平和胃粘膜DNA甲基化水平之间的关联。我们发现血清多酚水平（大豆黄酮、染料木素、（-）-表儿茶素、（-）-表儿茶素-3-没食子酸酯、（-）-表没食子儿茶素和（-）-表没食子儿茶素-3-没食子酸酯）与三种与胃癌风险相关的标志物的DNA甲基化水平之间没有关联。

项目成果

Effects of genome architecture and epigenetic factors on susceptibility of promoter CpG islands to aberrant DNA methylation induction.

• DOI: 10.1016/j.ygeno.2011.06.003
• 发表时间: 2011-09
• 期刊: Genomics
• 影响因子: 4.4
• 作者: Hideyuki Takeshima;S. Yamashita;T. Shimazu;T. Ushijima

Isoflavone intake and risk of gastric cancer: a population-based prospective cohort study in Japan

• DOI: 10.3945/ajcn.111.020479
• 发表时间: 2012-01-01
• 期刊: AMERICAN JOURNAL OF CLINICAL NUTRITION
• 影响因子: 7.1
• 作者: Hara, Azusa;Sasazuki, Shizuka;Tsugane, Shoichiro
• 通讯作者: Tsugane, Shoichiro