Role of endothelial lipase in anti-inflammatory properties of high-density lipoprotein

抑制内皮脂酶（EL）可增加血浆高密度脂蛋白胆固醇（HDL-C）水平。在这项研究中，我们评估了从EL-/-和WT小鼠分离的HDL的功能质量。HDL的抗炎功能，如PON-1或PAF-AH活性，抑制精氨酸诱导的VCAM-1表达，抑制LDL氧化，在WT和EL-/-小鼠之间相似。相反，EL-/-小鼠中HDL的脂多糖中和能力高于WT小鼠。静脉注射从EL-/-小鼠分离的HDL改善LPS处理的小鼠的死亡率。因此，EL失活增加了血浆HDL颗粒，保留了抗炎和抗动脉粥样硬化功能。

Inhibition of endothelial lipase(EL) increases plasma high-density lipoprotein cholesterol(HDL-C) level. In this study, we assessed the functional quality of HDL isolated from EL-/-and WT mice. Anti-inflammatory functions of HDL, such as PON-1 or PAF-AH activities, inhibition of cytokine-induced VCAM-1 expression, inhibition of LDL oxidation, were similar between WT and EL-/-mice. In contrast, lipopolysaccharideneutralizing capacity of HDL was higher in EL-/-mice than in WT mice. Intravenous injection of HDL isolated from EL-/-mice improved the mortality in LPS-treated mice. Thus, EL inactivation increased plasma HDL particles with preserved anti-inflammatory and anti-atherosclerotic functions.