Prevention of dementia by the recovery of the mastication

通过恢复咀嚼功能来预防痴呆症

• 批准号: 21592448
• 负责人: HARA Tetsuya
• 金额: $ 3万
• 依托单位: Okayama University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21592448/
• 关键词: 咀嚼; 記憶; 海馬; 認知症; 遺伝子; DNAアレイ; 歯; ラット; マイクロアレイ

The memory related gene expression in the rat hippocampus was analyzed by using the DNA microarray method. The gene expression of Trh and Tnxa increased when studying, and that of Nnat and S100a9 decreased. The number of errors of radial maze in the extraction group was more than that of the denture group and the control group. The time course of these 4 gene expression was observed by real-time PCR method. The gene expression of Tnxa Nnat and S100a9 showed the consistency with behavioral experiment result.

采用基因芯片技术分析大鼠海马记忆相关基因的表达。Trh和Tnxa的基因表达量在研究过程中增加，而Nnat和S100a9的基因表达量下降。拔牙组的径向迷宫错误次数多于义齿组和对照组。实时荧光定量PCR法观察4个基因表达的时程变化。Tnxa Nnat和S100a9基因的表达与行为学实验结果一致。

项目成果

咬合支持回復時の空間認知能に対する分散学習の影響

咬合支持恢复过程中分布式学习对空间认知的影响

• 发表时间: 2011
• 作者: 原哲也;黒住明正;坂本隼一;飯田祥与;荒木大介;黒田知沙;岡森彦;白井肇;森慎吾;衣田圭宏;皆木省吾
• 通讯作者: 皆木省吾

Influence of Molar Loss on Gene Expression in Hippocampus

摩尔损失对海马基因表达的影响

• 发表时间: 2010
• 作者: Hara T;Kawata K;Kurozumi A;Oka M;Kuroda C;Shimazu-Kodama C;Sakamoto S;Minagi S
• 通讯作者: Minagi S

Spaced Training Facilitates Long-term Memory Retention in Molarless Rats

间隔训练有利于无磨牙大鼠的长期记忆保留

• 发表时间: 2011
• 作者: Hara T;Kurozumi A;Sakamoto S;Kuroda C;Oka M;Iida S;Araki D;Minagi S
• 通讯作者: Minagi S

Memory-related gene expression in the rat hippocampus by the learning

学习过程中大鼠海马记忆相关基因的表达

• 发表时间: 2012
• 作者: S. IIDA;D. ARAKI;T. HARA;C. KURODA;M. OKA;A. KUROZUMI;K. KAWATA;S. SAKAMOTO;T. MIYAZAKI and S.MINAGI
• 通讯作者: T. MIYAZAKI and S.MINAGI