Prevention of dementia by the recovery of the mastication

应用基因芯片技术分析记忆相关基因在大鼠海马区的表达。研究期间TRH和Tnxa基因表达增加，NNAT和S100A9基因表达降低。拔牙组径向迷宫错误次数明显多于义齿组和对照组。用实时荧光定量聚合酶链式反应方法观察这4种基因表达的时程变化。Tnxa、NNAT和S100A9的基因表达与行为学实验结果一致。

The memory related gene expression in the rat hippocampus was analyzed by using the DNA microarray method. The gene expression of Trh and Tnxa increased when studying, and that of Nnat and S100a9 decreased. The number of errors of radial maze in the extraction group was more than that of the denture group and the control group. The time course of these 4 gene expression was observed by real-time PCR method. The gene expression of Tnxa Nnat and S100a9 showed the consistency with behavioral experiment result.