Role of angiotensin II type 1 receptor in macrophage polarization and function
Role of angiotensin II type 1 receptor in macrophage polarization and function
批准号:
22790707
负责人:
SUZUKI Jun
金额:
$2.16万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2011
中文摘要
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英文摘要
Stimulation of the angiotensin II type 1 receptor induces macrophage polarization to inflammatory M1 state and activates macrophage phagocytic function. Angiotensin II type 1 receptor also plays an important role in oxidized LDL-induced macrophage trapping in the atherosclerotic lesions via enhancing CD36 expression and focal adhesion kinase activation. Our results suggest that stimulation of the angiotensin II type 1 receptor modulates macrophage polarity and functions, resulting in atherosclerotic plaque instability.
期刊论文(0)
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会议论文
Deletion of the Angiotensin II Type 1a Receptor Prevents Athero sclerotic Plaque Rupture
血管紧张素 II 1a 型受体的缺失可预防动脉粥样硬化斑块破裂
DOI:
--
发表时间:
2012
期刊:
Arterioscle Thromb Vasc Biol
影响因子:
--
作者:
[Jun Aono, Jun Suzuki, et al]
通讯作者:
et al
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