The measurement and the evaluation of chromogranin A in saliva as an objective index of the mental stress in psychosomatic disease

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Objective : It is generally thought that the factor of the external stress and the difference of sensitivity to the stress influence greatly on the occurrence and the progress in psychosomatic disease. In this regards, to estimate psychosomatic response quantitatively to the stress, we measured the concentration of chromogranin A in saliva. Methods : The 14 normal volunteers were requested to keep the rest condition for 30 minutes, then they received mental stress for 3 minutes. We measured the concentration of chromogranin A in saliva at 3 time points before, during and after the stress. Results : When-the stress was loaded, the concentration of chromogranin A in saliva (0.80±0.19 pmol/ml) increased significantly (p<0.05) compared with the concentration before the stress (0.32±0.08 pmol/ml). On the other hand, the concentrations of chromogranin A of outpatients who visited our hospital were measured. The concentrations of patients with depression (1.02±0.93 pmol/ml), those with panic disorder (1.56±1.78 pmol/ml), and those with white coat hypertension (8.97±6.50 pmol/ml), were all higher significantly than that of the normal volunteers (0.32±0.28 pmol/ml). Conclusions : These data suggested that the concentration of the chromogranin A in saliva increased transiently by the burden of the stress, and it might be a good quantitative index of the patients with psychosomatic disease.