The measurement and the evaluation of chromogranin A in saliva as an objective index of the mental stress in psychosomatic disease

唾液中嗜铬粒蛋白A作为心身疾病精神应激客观指标的测定与评价

• 批准号: 12670434
• 负责人: SUZUKI Jun
• 金额: $ 0.77万
• 依托单位: Iwate Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2000
• 资助国家: 日本
• 起止时间: 2000 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12670434/
• 关键词: chromogranin A; psychosomatic disease; depression; panic disorder; white coat hypertension; stress related diseases; 唾液中ストレスマーカー; chromogranin A; ストレス; 白衣高血圧; 自律神経機能; 抑うつ状態; 唾液中human chromogranin A; 精神的ストレス; 数値逆唱ストレス負荷

Objective : It is generally thought that the factor of the external stress and the difference of sensitivity to the stress influence greatly on the occurrence and the progress in psychosomatic disease. In this regards, to estimate psychosomatic response quantitatively to the stress, we measured the concentration of chromogranin A in saliva. Methods : The 14 normal volunteers were requested to keep the rest condition for 30 minutes, then they received mental stress for 3 minutes. We measured the concentration of chromogranin A in saliva at 3 time points before, during and after the stress. Results : When-the stress was loaded, the concentration of chromogranin A in saliva (0.80±0.19 pmol/ml) increased significantly (p<0.05) compared with the concentration before the stress (0.32±0.08 pmol/ml). On the other hand, the concentrations of chromogranin A of outpatients who visited our hospital were measured. The concentrations of patients with depression (1.02±0.93 pmol/ml), those with panic disorder (1.56±1.78 pmol/ml), and those with white coat hypertension (8.97±6.50 pmol/ml), were all higher significantly than that of the normal volunteers (0.32±0.28 pmol/ml). Conclusions : These data suggested that the concentration of the chromogranin A in saliva increased transiently by the burden of the stress, and it might be a good quantitative index of the patients with psychosomatic disease.

目的：外界应激因素及应激敏感性差异对心身疾病的发生和发展有重要影响。在这方面，为了定量估计对应激的心身反应，我们测量了唾液中嗜铬粒蛋白A的浓度。方法：14名正常志愿者先保持休息状态30分钟，再进行3分钟的精神应激。测定应激前、应激中、应激后3个时间点唾液中嗜铬粒蛋白A的浓度。结果：应激后，大鼠唾液中嗜铬粒蛋白A浓度（0.80±0.19 pmol/ml）较应激前（0.32±0.08 pmol/ml）显著升高（p<0.05）。另一方面，对来我院就诊的门诊患者进行了嗜铬粒蛋白A浓度测定。抑郁症患者（1.02±0.93 pmol/ml）、惊恐障碍患者（1.56±1.78 pmol/ml）、白大衣高血压患者（8.97±6.50 pmol/ml）的血药浓度均显著高于正常人（0.32±0.28 pmol/ml）。结论：唾液中嗜铬粒蛋白A浓度随应激负荷的增加而短暂升高，可作为心身疾病患者较好的定量指标。

项目成果

鈴木順, 星野健, 井上洋西 他: "精神的ストレスの客観的指標としての唾液中クロモグラニンA濃度測定"Jpn.J Psychosom Med. 41(4). 297-297 (2001)

Jun Suzuki、Ken Hoshino、Hironishi Inoue 等人：“唾液嗜铬粒蛋白 A 浓度的测量作为心理压力的客观指标”Jpn.J Psychosom Med 41(4) (2001)。

Suzuki Jun, Hoshino Ken, Inoue Hiroshi: "The measurement of human chromogranin A in saliva as an objective index of the mental stress"Jpn J Psychosom Med, 41 Suppl. 103 (2001)

铃木淳，星野健，井上宏：“唾液中人类嗜铬粒蛋白A的测量作为精神压力的客观指标”Jpn J Psychosom Med，41 Suppl。

鈴木順, 星野健, 井上洋西 他: "ストレス関連疾患における唾液中クロモグラニンA濃度の検討"Jpn.J Psychosom Med. 43(10)(印刷中). (2003)

Jun Suzuki、Ken Hoshino、Yonishi Inoue 等：“压力相关疾病中唾液嗜铬粒蛋白 A 浓度的研究”Jpn.J Psychosom Med 43(10)（出版中）。

Suzuki Jun, Hoshino Ken, Inoue Hiroshi: "The measurement of chromogranin A in saliva as an objective index of the mental stress"Jpn J Psychosom Med, 41(4). 297 (2001)

铃木淳，星野健，井上宏：“唾液中嗜铬粒蛋白A的测量作为精神压力的客观指标”Jpn J Psychosom Med，41（4）。

鈴木 順: "精神的ストレスの客観的指標としての唾液中ヒトクロモグラニンA濃度測定"Jpn J Psychosom Med. 41Supp.II. 103 (2001)

Jun Suzuki：“唾液中人嗜铬粒蛋白 A 浓度的测量作为心理压力的客观指标”Jpn J Psychosom Med 41Supp.II。