The role of lysophosphatidic acid in acute lung injury

为了阐明ATX和LPA在酸致肺损伤中的作用，我们检测了血液和BALF中ATX酶活性的变化。我们还研究了抗atx阻断抗体对酸诱导肺损伤进展的影响。我们观察到，酸灌注增加了BALF中ATX的酶活性。ATX活性的降低减弱了酸注入引起的肺通透性的增加。这些数据提示ATX及其产物LPA参与了酸致急性肺损伤肺水肿。

To elucidate the contribution of ATX and LPA to acid-induced lung injury, we examined the changes in the enzymatic activity of ATX in blood and BALF. We also examined the effect of anti-ATX blocking antibodies on the progression of acid-induced lung injury. We observed that acid instillation increased the enzymatic activity of ATX in BALF. Decreasing ATX activity attenuated the increased pulmonary permeability induced by acid-instillation. These data suggest that ATX and its product LPA are involved in pulmonary edema in acid-induced acute lung injury.