The role of lysophosphatidic acid in acute lung injury

溶血磷脂酸在急性肺损伤中的作用

• 批准号: 22790745
• 负责人: YAMADA Mitsuhiro
• 金额: $ 2.58万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22790745/
• 关键词: 急性肺損傷; 活性化脂質; 炎症; 組織修復; 細菌性肺炎; 急性肺傷害

To elucidate the contribution of ATX and LPA to acid-induced lung injury, we examined the changes in the enzymatic activity of ATX in blood and BALF. We also examined the effect of anti-ATX blocking antibodies on the progression of acid-induced lung injury. We observed that acid instillation increased the enzymatic activity of ATX in BALF. Decreasing ATX activity attenuated the increased pulmonary permeability induced by acid-instillation. These data suggest that ATX and its product LPA are involved in pulmonary edema in acid-induced acute lung injury.

为了阐明ATX和LPA在酸诱导的肺损伤中的作用，我们检测了血液和BALF中ATX酶活性的变化。我们还检查了抗ATX阻断抗体对酸诱导的肺损伤进展的影响。我们观察到，酸滴注增加的ATX在BALF中的酶活性。降低ATX活性可减弱酸滴注引起的肺通透性增加。这些数据表明，ATX及其产物LPA参与了酸诱导的急性肺损伤的肺水肿。

项目成果

急性肺損傷における肺好中球上CXCR4発現上昇の機序とその役割

肺中性粒细胞CXCR4表达增加在急性肺损伤中的机制及作用

• 发表时间: 2011
• 作者: Yamada M;Kitagawa M;Yano H;Tamamura H;Fujii N;Kaku M;et al.;山田充啓
• 通讯作者: 山田充啓

The increase in surface CXCR4 expression on lung extravascular neutrophils and its effects on neutrophils during endotoxin-induced lung injury

• DOI: 10.1038/cmi.2011.8
• 发表时间: 2011-07-01
• 期刊: CELLULAR & MOLECULAR IMMUNOLOGY
• 影响因子: 24.1
• 作者: Yamada, Mitsuhiro;Kubo, Hiroshi;Kaku, Mitsuo
• 通讯作者: Kaku, Mitsuo