Studies on host defense mechanisms of pulmonary collectins against Legionella pneumophila.

肺凝集素在肺的天然免疫中起重要作用。在这项研究中，我们发现，肺收集素减弱自噬诱导的L。嗜肺菌感染此外，肺凝集素还能抑制L.嗜肺菌这些结果表明，肺凝集素保护宿主细胞的以前未知的宿主防御机制对细胞内病原体。

Pulmonary collectins play important roles in innate immunity of the lung. In this study, we found that pulmonary collectins attenuate autophagy induced by L. pneumophila infection. Furthermore, pulmonary collectins inhibit the secretion of effector molecules into host cells via type IV secretion system of L. pneumophila. These results suggest that pulmonary collectins protect host cells by the previously uncharacterized host defense mechanism against intracellular pathogen.