Analysis of neural metabolites of optic nerve disease using high-spatial-resolution MRI

我们研究了在体内的视神经疾病的神经代谢物的分析质子磁共振波谱（1H-MRS）3-Tesal高分辨率MRI。我们可以测量人类视觉皮层（V1）中皮质代谢物的浓度。重度视神经萎缩组V1区N-乙酰天门冬氨酸（NAA）含量较正常对照组降低。在青光眼性视神经萎缩中，NAA的降低与视野缺损的严重程度相关。在体外实验研究中，使用7特斯拉MRI的1H-MRS显示青光眼模型大鼠在慢性疾病阶段的V1中NAA减少。

We investigated the analysis of neural metabolites in optic nerve diseases in vivo by proton magnetic resonance spectroscopy(1H-MRS) on 3-Tesal high resolution MRI. We could measure the concentration of cortical metabolites in the human visual cortex (V1). The N-acetyl aspartate (NAA) of the V1 in the severe optic atrophy reduced compared with normal control group. In glaucomatous optic atrophy, the reduction of NAA was associated with the severity of visual field defects. In an experimental in vitro study, 1H-MRS using 7-Tesla MRI revealed reduced NAA in V1 of glaucoma model rats during the chronic disease phase by.