Development of intestinal regeneration in vivo using polyglycolic acid felt as a extracellular matrix.

本研究的目的是使用神经肽蛙皮素在大鼠肠再生。但已阐明，蛙皮素的施用不足以使肌肉层适当地再生具有正常粘膜结构。由于时间和费用的限制，我们将本研究的目的从肠再生改为用同样的神经肽在CDH大鼠模型上进行肺再生，用妊娠SD大鼠（22胎龄），于第9.5天经鼻胃管给予100 mg的除草醚，发现蛙皮素剂量依赖性地增加CDH大鼠的肺重/体重比（LW/BW）。

The aim of this study was intestinal regeneration using neuropeptide bombesin in rats. But it was elucidated that administration of bombesin was not enough to regenerate muscle layer properly with normal mucosal structure. Because of the limit of time and cost, we changed the purpose of this project from intestinal regeneration to lung regeneration with the same neuropeptide using CDH rat model.Using pregnant Sprague-Dawley (SD) rat(term22) which received 100mg of nitrofen into stomach through nasogastric tube on day 9.5, it was found that lung weight to body weight ratio(LW/BW) in CDH rat increases bombesin dose-dependently.