Development of intestinal regeneration in vivo using polyglycolic acid felt as a extracellular matrix.

本研究的目的是利用神经肽蛙皮素对大鼠进行肠道再生。但已有研究表明，蛙皮素的应用不足以使肌层正常再生，并具有正常的粘膜结构。由于时间和成本的限制，我们使用相同神经肽的CDH大鼠模型，将该项目的目的从肠道再生改为肺再生。使用怀孕的Spraogue-Dawley(SD)大鼠(Term22)，在第9.5天通过鼻胃管给予100 mg硝芬，发现CDH大鼠的肺重量/体重比(LW/BW)增加，并呈剂量依赖关系。

The aim of this study was intestinal regeneration using neuropeptide bombesin in rats. But it was elucidated that administration of bombesin was not enough to regenerate muscle layer properly with normal mucosal structure. Because of the limit of time and cost, we changed the purpose of this project from intestinal regeneration to lung regeneration with the same neuropeptide using CDH rat model.Using pregnant Sprague-Dawley (SD) rat(term22) which received 100mg of nitrofen into stomach through nasogastric tube on day 9.5, it was found that lung weight to body weight ratio(LW/BW) in CDH rat increases bombesin dose-dependently.