Development of intestinal regeneration in vivo using polyglycolic acid felt as a extracellular matrix.

本研究的目的是利用神经肽炸弹素对大鼠进行肠道再生。结果表明，在粘膜结构正常的情况下，给药bombesin不足以使肌肉层正常再生。由于时间和成本的限制，我们使用CDH大鼠模型，将本项目的目的从肠道再生改为使用相同的神经肽进行肺再生。采用妊娠SD大鼠（第22期），于第9.5天经鼻胃管灌胃给予100mg硝芬，发现CDH大鼠肺重/体重比（LW/BW）呈剂量依赖性增加。

The aim of this study was intestinal regeneration using neuropeptide bombesin in rats. But it was elucidated that administration of bombesin was not enough to regenerate muscle layer properly with normal mucosal structure. Because of the limit of time and cost, we changed the purpose of this project from intestinal regeneration to lung regeneration with the same neuropeptide using CDH rat model.Using pregnant Sprague-Dawley (SD) rat(term22) which received 100mg of nitrofen into stomach through nasogastric tube on day 9.5, it was found that lung weight to body weight ratio(LW/BW) in CDH rat increases bombesin dose-dependently.