Functional analysis of specific activation factor and elucidation of the tumorangiogenesis in hepatoblastoma stem cells

肝母细胞瘤肿瘤干细胞（CSCs）的鉴定和分析在阐明儿童癌症的致癌机制和发展新的治疗预后方面具有显著的挑战性。分离肝母细胞瘤细胞中的CSC，并在小鼠体内实验中鉴定这些细胞。我们还研究了CD133在人肝母细胞瘤细胞系中的分布。结果表明，CD133膜定位在肿瘤细胞粘附和迁移中起作用。此外，研究结果表明，CD133参与肿瘤血管生成。

The identification and analysis of hepatoblastoma Cancer stem cells（CSCs） can be significantly challenging in elucidating the carcinogenic mechanism of childhood cancerand developing a prognosis for a new therapy. CSCs in hepatoblastoma cells were separated,and these cells were identified in an in vivo experiment into mice. We also examined distribution of CD133 in a human hepatoblastoma cell-line. The results suggest that CD133 membrane localization plays a role in tumor cell adhesion and migration. Furthermore, the findings imply that CD133 is involved in tumor angiogenesis.