Analysis of expression and role of ADAMTS-9 on induced callus of ATDC5 for application to bone regeneration
Analysis of expression and role of ADAMTS-9 on induced callus of ATDC5 for application to bone regeneration
批准号:
22592037
负责人:
YAMAAI Yuichiro
金额:
$2.66万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012
中文摘要
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英文摘要
To apply to the bone regeneration, the roles of ADAMTS-9 or Notch family was analyzed by using induced chondroblasts from the pluripotential ATDC5 cells. Clusters obtained from ATDC5 cells cultured in STK3 medium were similar to endochondral ossification sites in vivo. ADAMTS-9 acts as inhibitory to cell proliferation and Notch1 was inhibitory to cluster formation. It was suggested that it is possible to contribute to activate the formation and the growth of clusters by using these antibodies in culture.
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抗ADAMTS-9とNotch1~4抗体によるATDC5細胞のtype-I、-IIコラーゲン発現と増殖活性変化
抗ADAMTS-9和Notch1~4抗体对ATDC5细胞I型和II型胶原蛋白表达及增殖活性的影响
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[Terayama R, Fujisawa N, Yamaguchi D, Omera S, Ichikawa H, Sugimoto T., 山合友一朗, 大村晋司, 山合友一朗, 寺山隆司, 山合友一朗]
通讯作者:
山合友一朗
と抗 Notch1~4 抗体 による ATDC5 細胞の type-I, -II コラー抗 ADAMTS-9 ン発現と増殖活性変化、
抗Notch1~4抗体和抗Notch1~4抗体对ATDC5细胞中Type-I、-II Collar抗ADAMTS-9表达和增殖活性的影响。
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[Terayama R, Fujisawa N, Yamaguchi D, Omera S, Ichikawa H, Sugimoto T., 山合友一朗, 大村晋司, 山合友一朗]
通讯作者:
山合友一朗
ATDC5細胞の軟骨細胞分化誘導 時の Notch1~4, PCNA の発現
ATDC5细胞软骨细胞分化诱导过程中Notch1~4和PCNA的表达
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Terayama R, Fujisawa N, Yamaguchi D, Omera S, Ichikawa H, Sugimoto T., 山合友一朗, 大村晋司, 山合友一朗, 寺山隆司, 山合友一朗, 寺山隆司, 寺山隆司, 山合友一朗]
通讯作者:
山合友一朗
ラット脛骨骨折治癒時のNotchとPCNA発現細胞の分布
大鼠胫骨骨折愈合过程中Notch和PCNA表达细胞的分布
DOI:
--
发表时间:
2011
期刊:
J.Oral Biosci
影响因子:
--
作者:
[Terayama R, Fujisawa N, Yamaguchi D, Omera S, Ichikawa H, Sugimoto T., 山合友一朗]
通讯作者:
山合友一朗
ATDC5細胞の軟骨細胞分化誘導時のNotch1~4とPCNAの発現
ATDC5细胞软骨细胞分化诱导过程中Notch1-4和PCNA的表达
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Terayama R, Fujisawa N, Yamaguchi D, Omera S, Ichikawa H, Sugimoto T., 山合友一朗, 大村晋司, 山合友一朗, 寺山隆司, 山合友一朗, 寺山隆司, 寺山隆司, 山合友一朗, 山合友一朗]
通讯作者:
山合友一朗
Expression of connective tissue growth factor CTGF in the callus during bone regeneration and application for acceleration of regeneration.
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批准号:17591908
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.24万
-
财政年份:2005
-
负责人:YAMAAI Yuichiro
-
依托单位:
The role of cells expressing connective tissue growth factor CTGF and ErbB4 receptor during regeneration and/or skeletomuscular development
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批准号:14571732
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.86万
-
财政年份:2002
-
负责人:YAMAAI Yuichiro
-
依托单位:
Analysis on the gene expression of CTGF, an endochondral ossification factor, during mouse development and its application for a bone regeneration
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批准号:12671770
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项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.05万
-
财政年份:2000
-
负责人:YAMAAI Yuichiro
-
依托单位:
Detection and analysis of a factor concerned with cell differentiation and growth during mouse molar tooth development by means of the grafting to a chick wing bud.
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批准号:06671810
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.41万
-
财政年份:1994
-
负责人:YAMAAI Yuichiro
-
依托单位:
海外基金