Investigation of the role of endogenous Wnt signaling in osteoclast differentiation and function

牙周炎是一种由牙周致病菌感染引起的慢性炎症性疾病，可引起牙槽骨吸收。牙槽骨吸收的特征在于增加的成骨细胞骨吸收超过成骨细胞的骨形成。本研究阐明了Wnt信号是控制细胞增殖、运动、分化、极性和形态发生的关键调节因子，在增强破骨细胞分化过程中的融合过程和骨细胞骨吸收相关基因的表达中起作用。

Periodontitis is a chronic inflammatory disease caused by infection of periodontopathic bacteriae, which induces alveolarbone resorption. The alveolar bone resorption is characterized by an increased osteoclastic bone resorption that exceeds the bone formation by osteoblasts. This study clarified that Wnt signaling, which is a critical regulator controlling cell proliferation, movement, differentiation, polarity, and morphogenesis, plays a role in the enhancement both the fusion process during osteoclast differentiation and the expression of osteoclastic bone resorption-related genes.