Are benign tumors transformed into malignant tumors? The morphological and molecular pathological analysis in salivary gland tumors

在涎腺肿瘤中，多形性腺瘤是出现频率最高的良性肿瘤，其发病时间长，易发生恶变。用非典型多形性腺瘤和癌以外的多形性腺瘤探讨良性肿瘤向恶性肿瘤转化的原因。P63免疫组织化学染色和EMA免疫组织化学染色均为阳性，肌上皮细胞和导管上皮细胞转化的部位变得清晰，证实参与DNA修复蛋白或细胞周期相关蛋白的部分过度表达。

In a tumor of salivary gland, a pleomorphic adenoma is a benign tumor with the highest frequency, and when it passes at a long period of time, carrying out malignant alteration is known. The cause which a benign tumor transforms into a malignant tumor was searched using the atypical pleomorphic adenoma and carcinoma ex pleomorphic-adenoma to which the benign part and the malignant part are intermingled in the same tumor. The part as which the malignant tumor was regarded showed p63 immunohistochemical staining and EMA immunohistochemical staining were positive, what both the myoepithelial cell and the ductal-epithelium cell transformed became clear, and it checked that the protein which participates in DNA repair protein or cell cycle related protein were over expressed by those parts.