Identification of emesis-inducing medullary neurons and anslysis of their functions.

我们研究了被称为化学感受器触发区的最后区域的神经元如何与恶心和/或呕吐的诱导以及对食物摄入量的控制有关。我们发现，表达H通道的神经元与恶心的诱导密切相关，但它们对被称为饱腹肽的胰淀素没有反应。对胰淀素的反应仅见于不表达H通道的神经元。我们的结论是，表达H通道的神经元和不表达H通道的神经元之间存在功能分化。

We investigated how neurons in the area postrema known as a chemoreceptor trigger zone are related to the induction of nausea and/or emesis and to the control of food intake. We found that the neurons expressing H channels are closely related to the induction of nausea but they do not respond to amylin that is known as a satiety peptide. Responses to amylin were found only in the neurons not expressing H channels. We concluded that these date suggested the presence of functional differentiation between the neurons expressing H channels and the neurons not expressing H channels.