A novel bisphosphonate with potent anabolic action for periodontitis

本研究旨在探讨新型双膦酸盐[4-(甲硫基)苯硫基]甲基双膦酸盐(MPMBP)促进骨形成的机制，以及该化合物是否具有治疗牙周炎的作用。结果表明，MPMBP可促进成骨相关基因的表达，对大鼠和犬实验性牙周炎有一定的治疗作用。MPMBP不仅可用于牙周炎的治疗，还可用于各种需要骨组织再生的疾病。

The current study was carried out to investigate by what mechanism a novel bisphosphonate, [4-(methylthio) phenylthio] methanebisphosphonate (MPMBP), can promote bone formation, and whether this compound can be effective on the periodontitis. Our results show that MPMBP promotes the expression of mRNA that relates osteogenesis, and that this compound was effective on the experimental periodontitis in rats and dogs. MPMBP may be used not only for the treatment of periodontitis, but also for various conditions that require the regeneration of bone tissues.