Control of orthodontic tooth movements by utilizing the inhibitory effect of bisphosphonates on bone resorption.

本研究的目的是检查双膦酸盐，骨吸收的强效阻滞剂，对正畸牙齿移动的影响。在1992年，我们研究了局部施用双膦酸盐（利塞膦酸盐）对大鼠正畸牙齿移动的影响。利塞膦酸钠的局部给药引起了显着的和剂量依赖性的减少牙齿移动后，正畸力的应用。利塞膦酸钠的局部给药也以剂量依赖性方式抑制牙齿复发。关于破骨细胞数量的结果表明，破骨细胞的形成被利塞膦酸盐的局部给药抑制。这些结果表明，局部应用利塞膦酸钠可能有助于在正畸治疗下锚定和保持牙齿。1993年，我们通过显微图像的图像分析测量了活动性骨吸收陷窝的大小，该图像直接输入到电视监视器，电视监视器上连接有摄像机。 ...更多信息 显微镜与对照侧相比，在利塞膦酸盐注射侧观察到活性骨吸收面积减少约50%。这表明破骨细胞的骨吸收活性在利塞膦酸盐注射侧降低。1994年，我们重新检查了组织切片，强调牙根吸收的变化。利塞膦酸钠治疗侧的牙根吸收面积明显小于对照侧。牙齿移动后，吸收的牙根面通过修复牙骨质的附着逐渐恢复。利塞膦酸钠治疗侧和对照侧的修复体之间无差异。在另一项研究中，3种双膦酸盐，AHBuBP，AHPrBP和Cl_2MBP对克隆成骨样细胞系MC 3 T3-E1的生长和成骨功能的影响进行了研究。结果提示，双膦酸盐促进成骨细胞的分化，抑制成骨细胞PGE_2的产生可能是其抑制骨吸收的机制之一。少

The purpose of this study was to examine the effect of bisphosphonates, potent blockers of bone resorption, on orthodonic tooth movements. In 1992, we examined the effect of topical administration of a bisphosphonate (risedronate) on orthodontic tooth movements in rats. The topical administration of risedronate caused a significant and dose-dependent reduction of tooth movement after the orthodontic force was applied. The topical administration of risedronate also inhibited relapse of the tooth in a dose-dependent manner. The results regarding the number of osteoclasts indicated that the formation of osteoclasts was inhibited by the topical administration of risedronate. These results suggest that topical application of risedronate may be helpful in anchoring and retaining teeth under orthodonic treatment. In 1993, we measured the sizes of active bone resorptive lacunae by image analysis of the microscopic image which was fed directly to a TV monitor with a video camera attached to the … More microscope. About a 50 % reduction of the active bone resorptive area was observed on the risedronate-injected side as compared with the control side. This suggests that the bone-resorbing activity of osteoclasts decreased on the risedronate-injected side. In 1994, we reexamined the histological sections, putting emphasis on root resorptive changes. On the risedronate-treated side, the area of root resorption was significantly smaller than that on the control side. After the tooth movement, resorbed root surfaces were gradually restored by apposition of repair cementum. There was no difference between the restoration on the risedronate-treated side and that on the control side. In another study, the effects of 3 bisphosphonates, AHBuBP,AHPrBP,and Cl_2MBP on growth and osteoblastic functions of the clonal osteoblast-like cell line MC3T3-E1 were examined. The results suggest that bisphosphonates facilitate the differentiation of osteoblasts and that the inhibition of PGE_2 production by osteoblasts may be involved in the mechanism of the inhibitory effect of bisphosphonates on bone resorption. Less