Study on development of a novel remedy using green tea catechin for Sjogren's syndrome

绿茶儿茶素治疗干燥综合征新药的开发研究

• 批准号: 22592082
• 负责人: SAITO Keiichi
• 金额: $ 2.91万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22592082/
• 关键词: 緑茶カテキン; シェーグレン症候群; Bax; Bcl-2; MRL/lprマウス; 活性酸素; JNK; MKP2

We administered epigallocatechin gallate (EGCG) to MRL-Faslprmice from age of 8 to 16weeks and examined suppressive effects of EGCG on autoimmune sialadenitis. Our results demonstrated that the rate of sialadenitis accompanied with tissue destruction decreased in EGCG-administered mice by 70% relative to EGCG-non-administered mice. The protective actions ofEGCG were ascribed to expression of heme oxygenase-1 and Bcl-2 which was enhanced by EGCG.

我们将表没食子儿茶素没食子酸酯（epigallocatechin gallate，EGCG）给予8 - 16周龄的MRL-Faslpr小鼠，并检查EGCG对自身免疫性涎腺炎的抑制作用。我们的研究结果表明，相对于未服用表没食子儿茶素没食子酸酯的小鼠，服用表没食子酸酯的小鼠的涎腺炎伴组织破坏的发生率降低了70%。EGCG的保护作用可能与其促进血红素氧合酶-1和Bcl-2的表达有关。

项目成果

DEVELOPMENT OF LOCALIZED GENE DELIVERY USING A DUAL-INTENSITY ULTRASOUND SYSTEM IN THE BLADDER

• DOI: 10.1016/j.ultrasmedbio.2010.07.015
• 发表时间: 2010-11-01
• 期刊: ULTRASOUND IN MEDICINE AND BIOLOGY
• 影响因子: 2.9
• 作者: Horie, Sachiko;Watanabe, Yukiko;Kodama, Tetsuya
• 通讯作者: Kodama, Tetsuya

Volumetric and Angiogenic Evaluation of Antitumor Effects with Acoustic Liposome and High-Frequency Ultrasound

• DOI: 10.1158/0008-5472.can-11-2389
• 发表时间: 2011-11-15
• 期刊: CANCER RESEARCH
• 影响因子: 11.2
• 作者: Kodama, Tetsuya;Tomita, Noriko;Mori, Shiro
• 通讯作者: Mori, Shiro

Evaluation of antitumoreffects following tumor necrosis factor-alphagene delivery using nanobubbles and ultrasound

使用纳米气泡和超声评估肿瘤坏死因子-α基因递送后的抗肿瘤效果

• DOI: 10.1111/j.1349-7006.2011.02084.x
• 发表时间: 2011
• 期刊: Cancer Sci
• 影响因子: 5.7
• 作者: Satoh Y;Yajima E;Murakami T;Shiro Mori(他4名)
• 通讯作者: Shiro Mori(他4名)

Epigallocatechin gallate inhibits oxidative stress-induced DNA damage and apoptosis in MRL-Fas(lpr) mice with autoimmune sialadenitis via upregulation of heme oxygenase-1 and Bcl-2

表没食子儿茶素没食子酸酯通过上调血红素加氧酶-1和Bcl-2抑制自身免疫性唾液腺炎MRL-Fas(lpr)小鼠氧化应激诱导的DNA损伤和细胞凋亡

• DOI: 10.3109/08916934.2013.850079
• 发表时间: 2014
• 期刊: Autoimmunity
• 影响因子: 3.5
• 作者: Keiichi Saito;Shiro Mori;Fumiko Date;Masao Ono
• 通讯作者: Masao Ono

Interface oral health science 2011

• DOI: 10.1007/978-4-431-54070-0
• 发表时间: 2012
• 作者: K. Sasaki;O. Suzuki;N. Takahashi;P. Stashenko;M. Cambridge