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Study on development of a novel remedy using green tea catechin for Sjogren's syndrome

Study on development of a novel remedy using green tea catechin for Sjogren's syndrome
绿茶儿茶素治疗干燥综合征新药的开发研究
批准号:
22592082
负责人:
SAITO Keiichi
金额:
$2.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012

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中文摘要
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英文摘要
We administered epigallocatechin gallate (EGCG) to MRL-Faslprmice from age of 8 to 16weeks and examined suppressive effects of EGCG on autoimmune sialadenitis. Our results demonstrated that the rate of sialadenitis accompanied with tissue destruction decreased in EGCG-administered mice by 70% relative to EGCG-non-administered mice. The protective actions ofEGCG were ascribed to expression of heme oxygenase-1 and Bcl-2 which was enhanced by EGCG.
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DOI: 10.1016/j.ultrasmedbio.2010.07.015
发表时间: 2010-11-01
期刊: ULTRASOUND IN MEDICINE AND BIOLOGY
影响因子: 2.9
作者: [Horie, Sachiko, Watanabe, Yukiko, Kodama, Tetsuya]
通讯作者: Kodama, Tetsuya
DOI: 10.1158/0008-5472.can-11-2389
发表时间: 2011-11-15
期刊: CANCER RESEARCH
影响因子: 11.2
作者: [Kodama, Tetsuya, Tomita, Noriko, Mori, Shiro]
通讯作者: Mori, Shiro
Evaluation of antitumoreffects following tumor necrosis factor-alphagene delivery using nanobubbles and ultrasound
使用纳米气泡和超声评估肿瘤坏死因子-α基因递送后的抗肿瘤效果
DOI: 10.1111/j.1349-7006.2011.02084.x
发表时间: 2011
期刊: Cancer Sci
影响因子: 5.7
作者: [Satoh Y, Yajima E, Murakami T, Shiro Mori(他4名)]
通讯作者: Shiro Mori(他4名)
Epigallocatechin gallate inhibits oxidative stress-induced DNA damage and apoptosis in MRL-Fas(lpr) mice with autoimmune sialadenitis via upregulation of heme oxygenase-1 and Bcl-2
表没食子儿茶素没食子酸酯通过上调血红素加氧酶-1和Bcl-2抑制自身免疫性唾液腺炎MRL-Fas(lpr)小鼠氧化应激诱导的DNA损伤和细胞凋亡
DOI: 10.3109/08916934.2013.850079
发表时间: 2014
期刊: Autoimmunity
影响因子: 3.5
作者: [Keiichi Saito, Shiro Mori, Fumiko Date, Masao Ono]
通讯作者: Masao Ono
10
    An investigation of cognitive strategies employed in intake interviews by expert practitioners in clinical psychology.
    • 批准号:
      22500243
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $1.41万
    • 财政年份:
      2010
    • 负责人:
      SAITO Keiichi
    • 依托单位:
    ROLES OF SALIVARY GLAND CELLS AS ANTIGEN PRESENTING CELLS IN PATHOGENESIS OF SJOGRENS SYNDROME
    • 批准号:
      17592175
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.33万
    • 财政年份:
      2005
    • 负责人:
      SAITO Keiichi
    • 依托单位:
    Development of visibility estimation model using colors and contrasts
    • 批准号:
      15500142
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $1.6万
    • 财政年份:
      2003
    • 负责人:
      SAITO Keiichi
    • 依托单位:
    INVOLVEMENT OF APOPTOTIC PATHWAY IN PATHOGENESIS OF SJOGRENS SYNDROME
    • 批准号:
      14571935
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.43万
    • 财政年份:
      2002
    • 负责人:
      SAITO Keiichi
    • 依托单位:
    海外基金