Basic research of inhibition of bone resorption on residual ridge using CNP hormone with local physiological effects.

具有局部生理效应的CNP激素抑制残牙槽骨吸收的基础研究。

• 批准号: 22592139
• 负责人: OKAYAMA Keisuke
• 金额: $ 2.91万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22592139/
• 关键词: 歯学; 骨; ホルモン; 骨形成; 動物実験

In this study, local bone formation effects of CNP hormone was examined to develop a new clinical treatment of inhabitation of bone resorption on residual ridge. The bone defect of 8.8 mm diameter to expose the dura mater was made in rat cranium. Hydrothermal hydroxyapatite containing saline solution and CNP hormone was prepared and implanted in the defect area. The new bone was formed from peripheral bone and dura mater. The area of newly formed bone increased to 4 weeks after implantation. No significant differences in new bone area showed between saline and CNP groups. The diffusion velocity of CNP hormone in local area should be examined to understand of the in vivo local effect of CNP hormone.

本研究通过观察CNP激素的局部成骨作用，为临床开发一种新的抑制牙槽骨吸收的治疗方法提供依据。在大鼠颅骨上造成直径为8.8mm的骨缺损，暴露硬脑膜。制备含盐溶液和CNP激素的水热羟基磷灰石，并植入缺损区。新生骨由周围骨和硬脑膜形成。植入后4周，新骨形成面积增加。生理盐水和CNP组之间的新骨面积无显著差异。应检查CNP激素在局部区域的扩散速度，以了解CNP激素的体内局部效应。