Basic research of inhibition of bone resorption on residual ridge using CNP hormone with local physiological effects.

本研究通过检测CNP激素对局部骨形成的影响，探索残脊骨吸收驻留的新的临床治疗方法。在大鼠头盖骨上制作直径8.8 mm暴露硬脑膜的骨缺损。制备含生理盐水和CNP激素的水热羟基磷灰石，植入缺损区。新骨由外周骨和硬脑膜形成。植入后4周，新生骨面积增加。生理盐水组和CNP组新生骨面积无显著差异。通过检测CNP激素在局部的扩散速度，了解CNP激素在体内的局部作用。

In this study, local bone formation effects of CNP hormone was examined to develop a new clinical treatment of inhabitation of bone resorption on residual ridge. The bone defect of 8.8 mm diameter to expose the dura mater was made in rat cranium. Hydrothermal hydroxyapatite containing saline solution and CNP hormone was prepared and implanted in the defect area. The new bone was formed from peripheral bone and dura mater. The area of newly formed bone increased to 4 weeks after implantation. No significant differences in new bone area showed between saline and CNP groups. The diffusion velocity of CNP hormone in local area should be examined to understand of the in vivo local effect of CNP hormone.