Genomic research for the receptive mechanism of mechanical stress andthe bone remodeling in the inner bone structure in residual ridge

为了研究生物力学应力诱导骨形成和炎症诱导骨吸收的机制，体外基因组研究了过度机械应力诱导骨形成相关的BMP信号和炎症细胞因子相关的TNF信号之间的串扰机制。本研究结果提供了稳定表达BMPRII的293细胞系中BMP信号受TNF-a调控的下游基因的全基因组图谱，为进一步分析BMP信号与TNF信号之间的串扰机制提供了有益的依据。

To examine mechanism of bone formation to biomechanical stress and bone resorption by inflammation, in vitro genomic investigation on the crosstalk mechanism between BMP signaling related to bone formation and TNF signalling related to inflammatory cytokine induced in over mechanical stress. The results in this study provide a genome-wide profile of the downstream genes of BMP signals that are regulated by TNF-a in a stable 293 cell line expressing BMPRII, which is useful for further analysis of the crosstalk mechanism between BMP signals and TNF signals.