The effects of occlusal activity on AChR clustering in mouse masticatory muscles

烟碱型乙酰胆碱受体（nAChR）成簇是神经肌肉接头（NMJ）突触发生的关键事件，NMJ是神经信号从运动神经元到骨骼肌的有效传递途径。本研究试图阐明阻塞的nAChR在咬肌的NMJ的集群的贡献，与mi/mi作为一个模型系统。目前的结果表明mi/mi咬肌NMJ中nAChR簇的异常形成，表明咬合对于NMJ中nAChR簇的正常进展至关重要。

Nicotinic acetylcholine receptor (nAChR) clustering is a key event in the synaptogenesis of the neuromuscular junction (NMJ) for the efficient transmission of neural signals from motor neurons to skeletal muscle. The present study attempted to elucidate the contribution of occlusion to the clustering of nAChR in the NMJ of the masseter, with mi/mi as a model system. The present results indicate abnormal formation of the nAChR cluster in the NMJ of the masseter of mi/mi, suggesting that occlusion is essential for the normal progress of nAChR clustering in the NMJ.