Clarification of pathogenic mechanism of PCR and development of the prevention method -a study with rat mandibular distraction model-

PCR致病机制的阐明及预防方法的开发-大鼠下颌牵张模型的研究-

• 批准号: 22592208
• 负责人: KOBAYASHI Tadaharu
• 金额: $ 2.83万
• 依托单位: Niigata University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22592208/
• 关键词: PCR; 発症メカニズム; 下顎骨延長; ラット実験モデル; マイクロ CT; ＰＣＲ; マイクロCT

This study was undertaken to examine the effects of mechanical loadings on the morphology of mandibular condyle following distraction in rat experimental model.10-week-old male Wistar rats received 3.5 mm unilateral mandibular distraction over 10 days after5-day latency period, and the morphological changes of mandibular condyles were examined one day, one week and three weeks after distraction. As a result, the deformation of the condyle with a destruction of cartilage layer and a bone resorption was recognized. These findings indicate thatoverloading to the mandibular condyle is a key factor for PCR.

本研究在大鼠实验模型上探讨机械载荷对牵张后下颌骨髁突形态的影响。10周龄雄性Wistar大鼠在5天潜伏期后接受3.5 mm单侧下颌骨牵张10天以上，观察牵张后1天、1周和3周下颌骨髁突的形态变化。结果，确认髁突变形，软骨层破坏和骨吸收。这些结果表明，下颌骨髁状突过载是PCR的关键因素。

项目成果

下顎骨前方移動術後のProgressive Condylar Resorption発症リスクの検討

检查下颌前移手术后发生进行性髁突吸收的风险

• 发表时间: 2012
• 作者: 小林正治;長谷部大地;船山昭典;三上俊彦;芳澤享子;齊藤力
• 通讯作者: 齊藤力

Effects of intermittent parathyroid hormone treatment on new bone formation during distraction osteogenesis in the rat mandible

• DOI: 10.1016/j.oooo.2011.08.009
• 发表时间: 2012-07-01
• 期刊: ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY
• 影响因子: 2.9
• 作者: Ali, Mir Nowazesh;Kobayashi, Tadaharu;Saito, Chikara
• 通讯作者: Saito, Chikara

ラット下顎骨延長モデルにおける顎関節の形態学的・組織学的検討 -力学的負荷が顎関節に及ぼす影響-

大鼠下颌伸展模型中颞下颌关节的形态学和组织学检查 -机械负荷对颞下颌关节的影响 -

• 发表时间: 2012
• 作者: 坂上直子;小林正治;小島拓;齊藤 力
• 通讯作者: 齊藤 力

Effects of surgical orthodontic treatment for dentofacial deformities on signs and symptoms of temporomandibular joint

• DOI: 10.1016/j.ajoms.2012.05.014
• 发表时间: 2013-01-01
• 期刊: JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY MEDICINE AND PATHOLOGY
• 影响因子: 0.4
• 作者: Togashi, Masaki;Kobayashi, Tadaharu;Saito, Chikara
• 通讯作者: Saito, Chikara

Effect of mechanical loading on the condyle in a rat mandibular distruction model

机械载荷对大鼠下颌骨破坏模型髁突的影响

• 发表时间: 2011
• 作者: 坂上直子;小林正治;小島拓;齊藤 力;緑川明憲;坂上直子
• 通讯作者: 坂上直子