The effects ofanesthetics onperipheral nerve regeneration

麻醉药物对周围神经再生的影响

• 批准号: 22592259
• 负责人: TOMIOKA Shigemasa
• 金额: $ 2.75万
• 依托单位: The University of Tokushima
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22592259/
• 关键词: 再生; 末梢神経; 麻酔薬; 骨髄間質細胞; 分化誘導

We differentiated murine bone marrow stromal cells (BMSCs) into Schwann cells in vitro. We suggests that BMSCs needs ascorbic acids and glutamic acids in the culture condition of differentiation into Schwann cells. We also examined the effects of general anesthetics and a local anesthetic onSchwann cells derived from BMSCs, which results suggest that a general anesthetic, propofol and a local anesthetic, lidocaine had the inhibitory effects on Schwann cells derived from BMSCs.

体外诱导小鼠骨髓基质细胞向雪旺细胞分化。提示BMSCs在向雪旺细胞分化的培养条件下需要抗坏血酸和谷氨酸。我们还研究了全身麻醉药和局麻药对BMSCs来源的雪旺细胞的影响，结果表明，全身麻醉药异丙酚和局麻药利多卡因对BMSCs来源的雪旺细胞有抑制作用。

项目成果

Leptin and vascular endothelial growth factor regulate angiogenesis in tooth germs

• DOI: 10.1007/s00418-011-0789-z
• 发表时间: 2011-03-01
• 期刊: HISTOCHEMISTRY AND CELL BIOLOGY
• 影响因子: 2.3
• 作者: Ide, Shinji;Tokuyama, Reiko;Satomura, Kazuhito
• 通讯作者: Satomura, Kazuhito

Pentobarbital inhibits glucose uptake, but not water transport by glucose transporter type 3

戊巴比妥抑制葡萄糖摄取，但不抑制 3 型葡萄糖转运蛋白的水转运

• DOI: 10.1097/wnr.0b013e328355d6fc
• 发表时间: 2012
• 期刊: NeuroReport
• 影响因子: 1.7
• 作者: Shigemasa Tomioka;Tatsumi Nagahama;Reiko Tokuyama,Seiko Tatehara;Kazuhito Satomura;Shigemasa Tomioka
• 通讯作者: Shigemasa Tomioka

Nerve growth factor increases electrical activity of neural cells derived from murine bone marrow stromal cells.

神经生长因子可增加源自小鼠骨髓基质细胞的神经细胞的电活动。

• 发表时间: 2012
• 期刊: Neuro - endocrinology letters
• 作者: S. Tomioka;T. Nagahama;Reiko Tokuyama;S. Tatehara;K. Satomura
• 通讯作者: K. Satomura

Expression and cellular localizaion of melatonin-synthesizing enzymes in rat and human salivary glands

• DOI: 10.1007/s00418-011-0800-8
• 发表时间: 2011-04-01
• 期刊: HISTOCHEMISTRY AND CELL BIOLOGY
• 影响因子: 2.3
• 作者: Shimozuma, Masashi;Tokuyama, Reiko;Satomura, Kazuhito
• 通讯作者: Satomura, Kazuhito