How periodontitis can affect prostate cancer metastasis?

牙周炎如何影响前列腺癌转移？

• 批准号: 22592312
• 负责人: TANIMOTO Ichiro
• 金额: $ 2.83万
• 依托单位: Okayama University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22592312/
• 关键词: 歯周炎; 慢性炎症; 癌転移; 歯周病; 慢性感染; がん転移

In the present study, we demonstrated the opposite association between localized and systemic inflammatory responses. Our finding suggests that appropriate infectious exposure might be needed to maintain our life. Taken together, a severe sepsis-like condition elicited by bacteremia, is likely responsible for the mortality associated with P. gingivalisinfection, but immune system would regulate the unwanted systemic responses. These systemic responses may alsoimpact metastatic cancer.

在本研究中，我们证明了局部和全身炎症反应之间的相反关联。我们的发现表明，适当的感染暴露可能是维持我们生命所必需的。综上所述，由菌血症引起的严重脓毒症样病症可能是与牙龈卟啉单胞菌感染相关的死亡率的原因，但免疫系统会调节不必要的全身反应。这些全身反应也可能影响转移性癌症。

项目成果

Secreted caveolin-1 enhances periodontal inflammation by targeting gingival fibroblasts

分泌的 Caveolin-1 通过靶向牙龈成纤维细胞增强牙周炎症

• 发表时间: 2013
• 期刊: Biomed. Res.
• 作者: Takizawa N;Sawada S;Chosa N;Ishisaki A;Naruishi K.
• 通讯作者: Naruishi K.

Naruishi K, Omori K, Maeda H, Sonoi N, Funakoshi K, Hirai K, Ishii M, Kubo K, Kobayashi H, Tomiyama T, Yamamoto D, Tanimoto I,Kunimatsu K, and Takashiba S

Naruishi K、Omori K、Maeda H、Sonoi N、Funakoshi K、Hirai K、Ishii M、Kubo K、小林 H、Tomiyama T、Yamamoto D、Tanimoto I、Kunimatsu K 和 Takashiba S

• 发表时间: 2011
• 期刊: J Biol Regul Homeost Agents
• 作者: Naruishi K;Omori K;Maeda H;Sonoi N;Funakoshi K;Hirai K;Ishii M;Kubo K;Kobayashi H;Tomiyama T;Yamamoto D;Tanimoto I,Kunimatsu K;and Takashiba S
• 通讯作者: and Takashiba S

Immune responses to porphyromonas gingivalis infection suppress systemic inflammatory response in experimental murine model.

• 发表时间: 2011-04
• 期刊: Journal of biological regulators and homeostatic agents
• 影响因子: 3.2
• 作者: Koji Naruishi;K. Omori;Hiroshi Maeda;Norihiro Sonoi;K. Funakoshi;Kimito Hirai;M. Ishii;K. Kubo;H. Kobayashi;T. Tomiyama;Daisuke Yamamoto;I. Tanimoto;Kazushi Kunimatsu;S. Takashiba