Direct involvement of periodontal disease on metabolic syndrome
Direct involvement of periodontal disease on metabolic syndrome
批准号:
22592322
负责人:
MATSUBARA Tatsuaki
金额:
$2.75万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012
中文摘要
为了研究牙周病对代谢综合征的直接影响,我们在大鼠中建立了结扎诱导的牙周炎。牙周炎大鼠血清甘油三酯水平明显高于正常大鼠。牙周炎大鼠主动脉TNF- α mRNA表达及单核细胞与内皮细胞粘附均显著增加。
英文摘要
To investigate a direct involvement of periodontal disease on metabolic syndrome, we developed ligature-induced periodontitis in rats. Serum triglyceride was significantly higher in periodontitis rats compared with normal rats. The mRNA expressions of TNF- α and monocyte adhesion to endothelial cells were significantly increased in aorta of periodontitis rats.
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The ratio of eicosapentaenoicacid to arachidonic acid is associated with lipid-rich coronary plaque.
二十碳五烯酸与花生四烯酸的比例与富含脂质的冠状动脉斑块相关。
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Aida J, Kondo K, Hirai H, Nakade M, Yamamoto T, Hanibuchi T, Osaka K, Sheiham A, Tsakos G, Watt RG, Domae E, 宍戸美香, 居波 薫, Amano T]
通讯作者:
Amano T
Impact of human dental pulp stem cell transplantation on diabetic polyneuropathy.
人牙髓干细胞移植对糖尿病多发性神经病的影响。
DOI:
--
发表时间:
期刊:
影响因子:
--
作者:
[Aida J, Nakade M, Hanibuchi T, Hirai H, Osaka K, Kondo K., Kaneda K., 秦正樹, Okusa C., 西川徹, Naruse K, Arishiro K., Hata M, Uetani T, 大草知佳, Naruse K]
通讯作者:
Naruse K
Anti-phosphorylcholine-opsonized low-density lipoprotein promotes rapid production of proinflammatory cytokines by dendritic cells and natural killer cells.
抗磷酸胆碱调理低密度脂蛋白促进树突状细胞和自然杀伤细胞快速产生促炎细胞因子。
DOI:
10.1111/j.1600-0765.2010.01292.x
发表时间:
2010
期刊:
Journal of periodontal research
影响因子:
3.5
作者:
[Kikuchi,T, ElShikh,MM, ElSayed,RM, Purkall,DB, Elaasser,MM, Sarraf,A, Barbour,SE, Schenkein,HA, Tew,JG]
通讯作者:
Tew,JG
Atorvastatin 10mg plus ezetimibe 10mg compared with atorvastatin 20mg : Impact on the lipid profile in Japanese patients with abnormal glucose tolerance and coronary artery disease
阿托伐他汀 10 毫克加依折麦布 10 毫克与阿托伐他汀 20 毫克相比:对日本糖耐量异常和冠状动脉疾病患者血脂的影响
DOI:
10.1016/j.jjcc.2011.09.001
发表时间:
2012
期刊:
Journal of Cardiology
影响因子:
2.5
作者:
[Kumagai S, Matsubara T, Uemura Y]
通讯作者:
Uemura Y
糖尿病における歯周病増悪メカニズム-ラットにおける検討-
糖尿病牙周病加重的机制 - 大鼠研究 -
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Aida J, Nakade M, Hanibuchi T, Hirai H, Osaka K, Kondo K., Kaneda K., 秦正樹, Okusa C., 西川徹]
通讯作者:
西川徹
共 27 条
Construction of an epigenetic epidemiology database for a population cohort
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批准号:25293144
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.4万
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财政年份:2013
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负责人:MATSUBARA Tatsuaki
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依托单位:
Integrative Study for the Impacts of Periodontal Disease on Metabolic Syndrome
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批准号:18592271
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.45万
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财政年份:2006
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负责人:MATSUBARA Tatsuaki
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依托单位:
海外基金