Development of new therapy for neuropathic cancer pain

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Using a mouse model for neuropathic cancer pain, we found that the antinociceptive effects of morphine, oxycodone and methadone were markedly suppressed inthe neuropathic cancer pain. We also found that the antinociceptive effects of morphine, fentanyl and oxycodone are mediated through the activation ofμ-opioid receptor splice variants containing the sequences encoded by exon -1 or exon-4, whereas the antinociceptive effect of amidino-TAPA, which is a new analgesic effective against neuropathic pain, is mediated through the activation of μ -opioid receptor splice variants containing the sequences encoded by exon-1, exon-4, exon-12, exon-13orexon-14.