Development of new therapy for neuropathic cancer pain

开发神经性癌痛新疗法

• 批准号: 22600009
• 负责人: SAKURADA Shinobu
• 金额: $ 2.83万
• 依托单位: Tohoku Pharmaceutical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22600009/
• 关键词: 癌性疼痛; 鎮痛; オピオイドペプチド; μ受容体; ジーンセラピー

Using a mouse model for neuropathic cancer pain, we found that the antinociceptive effects of morphine, oxycodone and methadone were markedly suppressed inthe neuropathic cancer pain. We also found that the antinociceptive effects of morphine, fentanyl and oxycodone are mediated through the activation ofμ-opioid receptor splice variants containing the sequences encoded by exon -1 or exon-4, whereas the antinociceptive effect of amidino-TAPA, which is a new analgesic effective against neuropathic pain, is mediated through the activation of μ -opioid receptor splice variants containing the sequences encoded by exon-1, exon-4, exon-12, exon-13orexon-14.

利用小鼠神经性癌痛模型，我们发现吗啡、羟考酮和美沙酮的抗伤害性作用在神经性癌痛中被显著抑制。我们还发现，吗啡、芬太尼和羟考酮的抗伤害作用是通过激活含有外显子1或外显子4编码序列的μ-阿片受体剪接变体介导的，而脒基-TAPA（其是一种有效对抗神经性疼痛的新型镇痛剂）的抗伤害作用是通过激活含有外显子1编码序列的μ-阿片受体剪接变体介导的，外显子4，外显子12，外显子13，外显子14。

项目成果

Intraplantar injection of bergamot essential oil induces peripheral antinociception mediated by opioid mechanism

• DOI: 10.1016/j.pbb.2010.09.020
• 发表时间: 2011-01-01
• 期刊: PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
• 影响因子: 3.6
• 作者: Sakurada, Tsukasa;Mizoguchi, Hirokazu;Sakurada, Shinobu
• 通讯作者: Sakurada, Shinobu

痛みとかゆみの受容におけるヒスタミン受容体の役割

组胺受体在疼痛和瘙痒接收中的作用

• 发表时间: 2010
• 作者: Ryo Odagiri;Yuriko Endo;Yuta Aoki;Hirokazu Mizoguchi;Shinobu Sakurada;大槻明日奈;小田桐遼;Shinobu Sakurada;勝山壮;青木祐太;青木祐太;青木祐太;青木祐太;青木祐太;青木祐太;小田桐遼;青木祐太;青木祐太;小田桐遼;大槻明日奈;青木祐太;溝口広一;大槻明日奈;溝口広一;青木祐太;Shota Fujiwara;Ryo Odagiri;Asuna Otsuki;Yuta Aoki;Yuta Aoki;Asuna Otsuki;Ryo Odagiri;Shota Fujiwara;Hiroyuki Watanabe;東谷崇之;徳永幸子;木祐太;櫻田忍
• 通讯作者: 櫻田忍

Lack of the rewarding effect and locomotor-enhancing effect of mu-opioid receptor agonist amidino-TAPA

mu-阿片受体激动剂脒基-TAPA缺乏奖赏作用和运动增强作用

• 发表时间: 2010
• 作者: Ryo Odagiri;Yuriko Endo;Yuta Aoki;Hirokazu Mizoguchi;Shinobu Sakurada;大槻明日奈;小田桐遼;Shinobu Sakurada;勝山壮;青木祐太;青木祐太;青木祐太;青木祐太;青木祐太;青木祐太;小田桐遼;青木祐太;青木祐太;小田桐遼;大槻明日奈;青木祐太;溝口広一;大槻明日奈;溝口広一;青木祐太;Shota Fujiwara;Ryo Odagiri;Asuna Otsuki;Yuta Aoki;Yuta Aoki;Asuna Otsuki;Ryo Odagiri;Shota Fujiwara;Hiroyuki Watanabe;東谷崇之;徳永幸子;木祐太;櫻田忍;波岡陽子;真井健吾;東谷崇之;渡辺千寿子;渡辺千寿子;真井健吾;Hirokazu Mizoguchi;Hirokazu Mizoguchi;Yu Banya
• 通讯作者: Yu Banya

Neuropathic pain promotes the expression of the autophagic markers LC3 and beclin in the mouse spinal cord

神经性疼痛促进小鼠脊髓中自噬标记物 LC3 和 beclin 的表达

• 发表时间: 2010
• 作者: Ryo Odagiri;Yuriko Endo;Yuta Aoki;Hirokazu Mizoguchi;Shinobu Sakurada;大槻明日奈;小田桐遼;Shinobu Sakurada;勝山壮;青木祐太;青木祐太;青木祐太;青木祐太;青木祐太;青木祐太;小田桐遼;青木祐太;青木祐太;小田桐遼;大槻明日奈;青木祐太;溝口広一;大槻明日奈;溝口広一;青木祐太;Shota Fujiwara;Ryo Odagiri;Asuna Otsuki;Yuta Aoki;Yuta Aoki;Asuna Otsuki;Ryo Odagiri;Shota Fujiwara;Hiroyuki Watanabe;東谷崇之;徳永幸子;木祐太;櫻田忍;波岡陽子;真井健吾;東谷崇之;渡辺千寿子;渡辺千寿子;真井健吾;Hirokazu Mizoguchi;Hirokazu Mizoguchi;Yu Banya;Yuta Aoki;Yukiko Tokunaga;Takaaki Komatsu;Kazuhiko Yanai;Laura Berliocchi;Hiroyuki Watanabe;Maria Maiaru
• 通讯作者: Maria Maiaru

Antinociceptive mechanism of epibatidine anlogue ABT-594 in mice

Epibatidine类似物ABT-594对小鼠的镇痛机制

• 发表时间: 2010
• 作者: Ryo Odagiri;Yuriko Endo;Yuta Aoki;Hirokazu Mizoguchi;Shinobu Sakurada;大槻明日奈;小田桐遼;Shinobu Sakurada;勝山壮;青木祐太;青木祐太;青木祐太;青木祐太;青木祐太;青木祐太;小田桐遼;青木祐太;青木祐太;小田桐遼;大槻明日奈;青木祐太;溝口広一;大槻明日奈;溝口広一;青木祐太;Shota Fujiwara;Ryo Odagiri;Asuna Otsuki;Yuta Aoki;Yuta Aoki;Asuna Otsuki;Ryo Odagiri;Shota Fujiwara;Hiroyuki Watanabe;東谷崇之;徳永幸子;木祐太;櫻田忍;波岡陽子;真井健吾;東谷崇之;渡辺千寿子;渡辺千寿子;真井健吾;Hirokazu Mizoguchi;Hirokazu Mizoguchi;Yu Banya;Yuta Aoki;Yukiko Tokunaga;Takaaki Komatsu;Kazuhiko Yanai;Laura Berliocchi;Hiroyuki Watanabe;Maria Maiaru;Takafumi Hayashi
• 通讯作者: Takafumi Hayashi