Mechanisms underlying a failure of Neuro-Endocrine-Immune system by chronic stress.

压力是现代生活中常见的一个方面，在许多疾病的病因中起着重要作用，如慢性疲劳综合征（CFS）和纤维肌痛（FM）。在本研究项目中，我们试图从分子和形态学的基础上分析神经内分泌免疫相关器官的疾病。我们在脑垂体中发现了许多分子表达的变化，有趣的是，大多数表达是由下丘脑的变化引起的，如释放激素表达的改变。这表明长期应激导致下丘脑神经元活性和分子表达的变化，不仅影响神经内分泌系统，而且影响自主神经系统，导致神经内分泌免疫系统完整性的破坏。

Stress is a common aspect of modern life and plays a role in the etiology of many diseases such as chronic fatigue syndrome(CFS) and fibromyalgia(FM). In this research project we attempted to analyze disorders of Neuro-Endocrine-Immune associated organs from molecular and morphological basis. We identified many changes in expression of molecules in pituitary gland and intriguingly most of expressions were elicited by hypothalamic changes such as alterations of expression of releasing hormones. This suggests that changes of neuronal activity and molecular expressions in hypothalamus due to a prolonged stress could affect neuroendocrine system as well as autonomic system, which lead to a failure of integrity of Neuro-Endocrine-Immune systems.