Mechanisms underlying a failure of Neuro-Endocrine-Immune system by chronic stress.

压力是现代生活中常见的一个方面，并在许多疾病的病因学中发挥作用，如慢性疲劳综合征（CFS）和纤维肌痛（FM）。本研究试图从分子和形态学基础上分析神经内分泌免疫相关器官的疾病。我们在垂体中发现了许多分子表达的变化，有趣的是，大多数表达是由下丘脑的变化引起的，如释放激素的表达改变。提示长期应激引起的下丘脑神经元活动和分子表达的变化，不仅影响神经内分泌系统，也影响自主神经系统，从而导致神经-内分泌-免疫系统的完整性丧失。

Stress is a common aspect of modern life and plays a role in the etiology of many diseases such as chronic fatigue syndrome(CFS) and fibromyalgia(FM). In this research project we attempted to analyze disorders of Neuro-Endocrine-Immune associated organs from molecular and morphological basis. We identified many changes in expression of molecules in pituitary gland and intriguingly most of expressions were elicited by hypothalamic changes such as alterations of expression of releasing hormones. This suggests that changes of neuronal activity and molecular expressions in hypothalamus due to a prolonged stress could affect neuroendocrine system as well as autonomic system, which lead to a failure of integrity of Neuro-Endocrine-Immune systems.