Identification of a transcription factor complex which promotes nerve regeneration

神经损伤需要大量基因的表达。这种基因在受损神经元中转录调控的关键分子机制知之甚少。我们假设存在一个转录因子复合体，它促进多种神经损伤相关分子的表达。在这项研究中，我们已经确定了一个启动子复合物组成的4个转录因子，ATF 3，c-Jun，STAT 3和Sp1。该复合物显著促进神经损伤相关蛋白如DINE和SOD的表达。这可能是一种有效的转录因子复合物，特别是对神经再生。

Nerve injury requires the expression of large ensembles of genes. The key molecular mechanism for this gene transcription regulation in injured neurons was poorly understood. We hypothesized an existence of transcription factor complex, which promoted expressions of multiple nerve injury associated molecules. In this study we have identified a promoter complex consisting of 4 transcription factors, ATF3, c-Jun, STAT3 and Sp1. This complex substantially promoted expression of nerve injury associated proteins such as DINE and SOD. This could be one of potent transcription factor complexes especially for nerve regeneration.