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Inhibitory effects of exercise on progression of obesity-related liver diseases and development of glyco-biomarkers to scale the pathophysiology of the liver diseases

运动对肥胖相关肝病进展的抑制作用以及糖生物标志物的开发以衡量肝病的病理生理学

基本信息

批准号：
22650162
负责人：
SHODA Junichi
金额：
$ 2.07万
依托单位：
University of Tsukuba
依托单位国家：
日本
项目类别：
Grant-in-Aid for Challenging Exploratory Research
财政年份：
2010
资助国家：
日本
起止时间：
2010 至 2011
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22650162/
关键词：
肥満脂肪性肝疾患運動療法糖鎖医学バイオマーカー

项目摘要

In management of obesity-related liver diseases, that is, non-alcoholic fatty liver diseases, it is important to increase a utilization of glucose in the skeletal muscles and thereby to improve the insulin-resistance. Therefore, in subjects with non-alcoholic fatty liver diseases, it is also important to maintain the volume of skeletal muscles by appropriate exercise. In the assessment of effects of exercise on liver pathophysiology of non-alcoholic fatty liver diseases, we need to explore novel biomarkers that can reflect the status of liver pathophysiology in terms of steatosis, inflammation, and fibrosis, and to develop a non-invasive measurement system of these biomarkers. In this research project, using the serum samples of middle-aged obese men who joined a weight-losing course, we explored novel biomarkers that can scale the improvement of liver pathophysiology induced by exercise. We measured an enzyme activity of N-acetylglucosaminyltransferase V (GnT-V) in the serum samples as a glyco-biomaker. Exercise increased the energy consumption, maintained the lean body mass, and decreased the serum levels of ferritin and TBARS, an oxidative stress marker, in comparison with diet restriction. Taken together, it is likely that serum levels of ferritin and TBARS are useful biomarkers to scale the effects of exercise on liver pathophysiology in obese men. Exploration of novel glycol-biomarkers is being performed.

在肥胖相关肝病（即，非酒精性脂肪性肝病）的管理中，重要的是增加骨骼肌中葡萄糖的利用，从而改善胰岛素抵抗。因此，在非酒精性脂肪肝患者中，通过适当的运动来维持骨骼肌的体积也很重要。在评估运动对非酒精性脂肪性肝病肝脏病理生理学的影响时，我们需要探索新的生物标志物，这些生物标志物可以反映脂肪变性，炎症和纤维化方面的肝脏病理生理学状态，并开发这些生物标志物的非侵入性测量系统。在这个研究项目中，使用参加减肥课程的中年肥胖男性的血清样本，我们探索了新的生物标志物，可以衡量运动引起的肝脏病理生理学的改善。我们测量了血清样品中作为糖生物标志物的N-乙酰氨基葡萄糖转移酶V（GnT-V）的酶活性。与饮食限制相比，运动增加了能量消耗，保持了瘦体重，降低了血清铁蛋白和氧化应激标志物TBARS的水平。总之，血清铁蛋白和TBARS水平可能是衡量运动对肥胖男性肝脏病理生理学影响的有用生物标志物。正在进行新的二醇生物标志物的探索。