Correlation analysis of diet and estrogen concentrations in the human body according to the incidence of estrogen-dependent cancers

根据雌激素依赖性癌症发病率进行饮食与人体内雌激素浓度的相关性分析

• 批准号: 22650239
• 负责人: HANDA Yasushi
• 金额: $ 2.05万
• 依托单位: Hokkaido University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22650239/
• 关键词: 遺伝子環境相互作用; 食の安全; 食肉; エストロゲン; 発癌

Estrogen concentrations in meat were compared by country regarding beef and chicken produced in Japan, the Philippines, and the United States. Beef and chicken produced in the US showed the highest estrogen levels. The lowest estrogen levels in beef were seen in Japanese beef. Estradiol levels of fat in beef produced in the Philippines were 8 times higher than Japanese beef. The lowest estrogen levels in chicken were seen in chicken produced in the Philippines. Estrone levels of chicken fat in Japanese chicken were 12 times higher than chicken in the Philippines. These differences were assumed to be due to residue of hormone agents externally administrated to the livestock. Estrogen concentrations in human adipose tissue were compared between Japan and the Philippines. Intra-tissue estrogen concentration measurement of fat tissues in post-menopausal women showed the Filipino women(n=6) have higher estrogen levels than Japanese women(n=15). Food Frequency Questionnaires showed different tendency of meat consumption between Japan and the Philippines. Difference in estrogen levels in human subcutaneous fat is difficult to be explained only by the estrogen concentrations in meat and food frequency questionnaire, and could not be ruled out the inability to compensate for differences in BMI due to low number of cases. In this study, we could not conclude the association between intake of meat after hormonal use and estrogen accumulation in human tissue, and relationship in the incidence of hormone-dependent cancer, until now. Further study is needed to review this result by increasing number of human samples

研究人员比较了日本、菲律宾和美国生产的牛肉和鸡肉中不同国家的雌激素浓度。美国生产的牛肉和鸡肉显示出最高的雌激素水平。牛肉中雌激素水平最低的是日本牛肉。菲律宾产牛肉中脂肪的雌二醇含量是日本牛肉的8倍。菲律宾产的鸡体内雌激素水平最低。日本鸡肉中鸡脂肪中的雌酮含量是菲律宾鸡肉的12倍。这些差异被认为是由于外部施用给牲畜的激素残留造成的。比较了日本和菲律宾人脂肪组织中的雌激素浓度。绝经后妇女脂肪组织内雌激素浓度测定显示，菲律宾妇女（n=6）的雌激素水平高于日本妇女（n=15）。食物频率调查显示，日本和菲律宾的肉类消费趋势不同。人皮下脂肪中雌激素水平的差异很难仅通过肉类和食物频率问卷中的雌激素浓度来解释，也不能排除病例数少而无法弥补BMI差异的可能。在本研究中，到目前为止，我们还不能得出激素使用后肉类摄入量与人体组织中雌激素积累的关系，以及与激素依赖性癌症发病率的关系。需要进一步的研究来通过增加人类样本的数量来审查这一结果

项目成果

Estrogen concentrations in beef and cancers : Does estrogen intake from meat relate to the incidence of hormone-dependent cancers?

牛肉中的雌激素浓度与癌症：从肉类中摄入的雌激素与激素依赖性癌症的发病率有关吗？

• 发表时间: 2010
• 作者: Y. Tomita;A. R. Kaneko;K. Hashiguchi;and S. Shirotake;Yasushi Handa
• 通讯作者: Yasushi Handa

Estrogen concentrations in beef and cancers : Does estrogen intake from meat relate to the incidence of hormone-dependent cancers

牛肉中的雌激素浓度与癌症：从肉类中摄入雌激素与激素依赖性癌症的发病率有关吗

• 发表时间: 2010
• 作者: 永田俊;楊燕輝;茂手木千晶;横川太一;Yasushi Handa
• 通讯作者: Yasushi Handa

Does estrogen intake from meat relate to the incidence of hormone-dependent cancers

从肉类中摄入雌激素与激素依赖性癌症的发病率有关吗

• 发表时间: 2010
• 作者: Y. Tomita;A. R. Kaneko;K. Hashiguchi;and S. Shirotake;Yasushi Handa;S.Shirotake;Yasushi Handa
• 通讯作者: Yasushi Handa

Does estrogen intake from meat relate to the incidence of hormone-dependent cancers?

从肉类中摄入的雌激素与激素依赖性癌症的发病率有关吗？

• 发表时间: 2010
• 作者: Y.Tomita;A.R.Kaneko;K.Hashiguchi;S.Shirotake;Yasushi Hands
• 通讯作者: Yasushi Hands

牛肉および癌組織のエストロゲン濃度-ホルモン剤使用牛肉の摂取と婦人科癌発生増加との関連-

牛肉中的雌激素浓度与癌症组织 - 摄入经过激素处理的牛肉与妇科癌症发病率增加之间的关系 -

• 发表时间: 2010
• 作者: Y.Tomita;A.R.Kaneko;K.Hashiguchi;S.Shirotake;Yasushi Hands;城武昇一;半田康
• 通讯作者: 半田康