Challenge for Detoxification of Arsenic by Methylated Metal Complex

甲基化金属络合物解砷的挑战

• 批准号: 22655018
• 负责人: HISAEDA Yoshio
• 金额: $ 2.23万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22655018/
• 关键词: 金属錯体化学; 無機ヒ素; メチル化反応; ビタミンB_<12>; グルタチオン; チオール; コバルト錯体; 有害化学物質; ビタミンB12; 触媒反応; 金属錯体; コバルト-メチル結合; 環境技術; ヒ素

Inorganic arsenic has caused serious chronic diseases throughenvironmental pollution. However, some methylated arsenic compounds, especiallytrimethylarsine oxide(TMAO) and arsenobatetaine(AB) have much lower toxicities thanarsenic trioxide(As2O3). The acute toxicity of AB, as determined from animal experiments, is approximately one three-hundredth of that of arsenic trioxide. Meanwhile, in marineecosystems, inorganic arsenicals are biologically methylated through the food chain, whichinvolves a methyltransferase and a reductase. An interesting application of the methyltransfer reaction with vitamin B_<12> to the detoxification system for inorganic arsenic hasbeen succeeded. This is a new and selective detoxification method for inorganic arsenic, which is the biomimetic methylation of arsenic trioxide(As2O3) to give trimethylarsineoxide(TMAO).

无机砷通过环境污染引起严重的慢性病。然而，一些甲基化砷化合物，特别是三甲基氧化砷（TMAO）和砷代甜菜碱（AB）的毒性远低于三氧化二砷（As2O3）。动物实验表明，AB的急性毒性约为三氧化二砷的三百分之一。同时，在海洋生态系统中，无机砷通过食物链发生生物甲基化，这涉及甲基转移酶和还原酶。本文报道了维生素B_的甲基转移反应<12>在无机砷解毒体系中的有趣应用。三氧化二砷（As_2O_3）仿生甲基化生成氧化三甲基砷（TMAO）是一种新的无机砷选择性解毒方法。

项目成果

Bioinsspired Catalysts with Vitamin B_12Enzyme Functions

具有维生素 B_12 酶功能的仿生催化剂

• 发表时间: 2012
• 作者: Hisaeda;Y
• 通讯作者: Y

Photo-induced ring-expansion reactions mediated by B12-TiO2 hybrid catalyst

• DOI: 10.1039/b921802e
• 发表时间: 2010-01-01
• 期刊: DALTON TRANSACTIONS
• 影响因子: 4
• 作者: Izumi, Shin-ichiro;Shimakoshi, Hisashi;Hisaeda, Yoshio
• 通讯作者: Hisaeda, Yoshio

Bioinspired Catalysts with Cyclic Tetrapyrrole Compounds

环状四吡咯化合物的仿生催化剂

• 发表时间: 2011
• 作者: 前川雄亮;大嶋孝志;林結希子;安倉和志;岩崎孝紀;真島和志;森田 明弘;Yoshio Hisaeda
• 通讯作者: Yoshio Hisaeda

Photosensitizing catalysis of B_<12> complex without additional photosensitizer

无需额外光敏剂的B_<12>配合物的光敏催化

• 发表时间: 2011
• 期刊: Chem.Commun.
• 作者: H.Shimakoshi;et al
• 通讯作者: et al

Handbook of Porphyrin Science, Vol.10 Bioinspired Catalysts with B_<12> Enzyme Functions

卟啉科学手册，第 10 卷具有 B_<12> 酶功能的仿生催化剂

• 发表时间: 2010
• 作者: Hisaeda;Y.;et al.
• 通讯作者: et al.