New Molecular Transformations Mediated by Bioinspired Catalysts

仿生催化剂介导的新分子转化

• 批准号: 21245016
• 负责人: HISAEDA Yoshio
• 金额: $ 14.64万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (A)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-21245016/
• 关键词: 生物無機化学; バイオインスパイアード; グリーンケミストリー; ビタミンB_<12>; 光増感剤; 脱ハロゲン化反応; 分岐高分子; ラジカル反応; ビタミンB12; 有機光増感剤; 光還元反応; ポルフィセン; イオンタグ; イオン液体; 光誘起電子移動; 二量化反応; モリブデン錯体; スズ錯体; 酸化チタン; 人血清アルブミン; 環拡大反応; 金属錯体; 人工酵素; バイオインスパイアード触媒

We have been interested in vitamin B_<12>-dependent enzymes, involving the cobalt species as a catalytic center, and dealing with a hydrophobic vitamin B_<12>, heptamethyl cobyrinate perchlorate, which has ester groups in place of the peripheral amide moieties of the naturally occurring vitamin B_<12>. In order to construct a good catalytic system, we prepared various nanomaterials with vitamin B_<12> activities. These bioinspired catalysts are very interesting from the viewpoint of green chemistry. 1,1-bis(4-chlorophenyl)-2,2,2-trichloroethane (DDT) is characterized by a pronounced insecticidal property and has been used worldwide for the last several decades despite its known hazardous effects on human health and wildlife. Because of recent environmental concerns, there is pressing need for efficient methods for degradation of such chlorinated compounds accumulated in the soil. DDT was degradated effectively by the bio-inspired catalysts with vitamin B_<12> function. Such bioinspired catalysts with vitamin B_<12> functions can apply not only the degradation of organic halide pollutants but also the organic synthesis via radical intermediates.

我们一直对依赖维生素B_12的酶感兴趣，涉及以钴为催化中心的物种，并处理疏水性维生素B_12&gt；高氯酸七甲基钴酸酯，它的酯基取代了自然产生的维生素B_12&gt；的外周酰胺部分。为了构建一个良好的催化体系，我们制备了各种具有维生素B_12活性的纳米材料。从绿色化学的角度来看，这些受生物启发的催化剂非常有趣。1，1-双(4-氯苯基)-2，2，2-三氯乙烷(DDT)具有显著的杀虫特性，尽管已知其对人类健康和野生动物有危害，但在过去几十年里已在全球范围内使用。由于最近的环境问题，迫切需要有效的方法来降解积聚在土壤中的这种氯化化合物。具有维生素B_12功能的仿生催化剂能有效地降解滴滴涕。这类具有维生素B12功能的仿生催化剂不仅可用于有机卤化物污染物的降解，还可用于自由基中间体的有机合成。

项目成果

Meso-Unsubstituted Iron Corrole in Hemoproteins: Remarkable Differences in Effects on Peroxidase Activities between Myoglobin and Horseradish Peroxidase

• DOI: 10.1021/ja907428e
• 发表时间: 2009-10-28
• 期刊: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
• 影响因子: 15
• 作者: Matsuo, Takashi;Hayashi, Akihiro;Hayashi, Takashi
• 通讯作者: Hayashi, Takashi

Preparations and photosensitizing properties of 2,7,12,17-tetra-n-propyl-porphycenatotin(IV)dihalide complexes

2,7,12,17-四正丙基卟啉锡(IV)二卤化物配合物的制备及其光敏性能

• 发表时间: 2010
• 期刊: Bulletin of the Chemical Society of Japan 83(in press)
• 作者: Masatsugu Taneda;et.al.
• 通讯作者: et.al.

Bioinsspired Catalysts with Vitamin B_12Enzyme Functions

具有维生素 B_12 酶功能的仿生催化剂

• 发表时间: 2012
• 作者: Hisaeda;Y
• 通讯作者: Y

ポルフィセン誘導体の光化学的挙動と酸化反応

卟啉衍生物的光化学行为和氧化反应

• 发表时间: 2011
• 作者: 久枝良雄;et al
• 通讯作者: et al

Photo-induced Dehalogenation Reactions Mediated by Hydrophobic Vitamin B12

疏水性维生素 B12 介导的光诱导脱卤反应

• 发表时间: 2010
• 作者: Hisaeda;Y
• 通讯作者: Y