Search for metabolic oscillator regulating food anticipatory activity

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Food anticipatory activities(FAA) are known to be induced by temporal restriction of feeding, and are regulated by a food-entrainable oscillator(FEO) located in the brain. One of the most important issues in this field is the localization of FEO and the molecular mechanisms of FEO. In this study, we developed an automated feeding apparatus that enables us to control the restricted feeding timing. Furthermore, we focused our attention to MBH as the brain region of FEO, and identified restricted-feeding response genes by microarray analysis of the MBH. The result should be valuable for approaching the molecular mechanisms of FEO.