Design of novel branched chain amino acids with metabolic control function for clinical improvement of lifestyle diseases.

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In this study, we attempted to construct novel synthetic procedures for the physiologically active amino acid production, such as hydroxylated branched chain amino acid derivatives, using enzymes involved in newly found microbial branched chain amino acid metabolisms. As the results, streroselectve fine syntheses, such as hydroxylated aliphatic amino acids by dioxygenases, hydroxylated amino acids by aldolases, and 4-hydroxyisoleucine stereoisomers by oxidoreductases were established.