Study on the absorpt i on of b i oact i ye pept i des depend i ng on the onset of diseases

本研究为了阐明疾病发生对生物活性小肽吸收的影响，初步建立了稳定同位素标记LCMRM-MS/MS连续测定大鼠血液中多肽的方法。利用这种新方法，首次观察到SHRs中Trp-His的吸收率比正常大鼠高约2倍。

In this study, in order to elucidate effect of the onset of diseases on absorption of bioactive small peptides, a stable isotope labeling LCMRM-MS/MS method forsuccessive determination of peptides in rat blood was primarily developed. By using this newly developed assay method, ca. 2-times higher absorption of one of dipeptides, Trp-His in SHRs was observed for the first time, compared to normal rats.