Mechanical stimulation-induced vascular elastogenesis

血管弹性纤维在维持动脉结构方面起着非常重要的作用。弹性纤维形成障碍与衰老和血管疾病密切相关。我们假设动脉上的机械应力会影响弹性纤维的形成。因此，我们试图对弹性纤维的形成与机械应力的类型和强度之间的关系进行定量分析。我们发现弹性纤维的形成在多层平滑肌细胞或循环拉伸中被促进。

Vascular elastic fibers play a very important role in maintaining the structure of the arteries. The impairment of elastic fiber formation is closely related with aging and vascular diseases. We hypothesized that mecanical stresses onto the arteries would affect elastic fiber formation. Therefore, we tried to perform the quantitative analysis of the relation between elastic fiber formation and the types and strength of mechanical stresses. We found that elastic fiber formation was promoted in multi-layers of smooth muscle cells or by cycle stretch.