Mechanical stimulation-induced vascular elastogenesis

机械刺激诱导血管弹性生成

• 批准号: 22659045
• 负责人: MINAMISAWA Susumu
• 金额: $ 2万
• 依托单位: Waseda University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22659045/
• 关键词: 組織工学; 形態形成; 細胞間相互作用; 機械的刺激; 弾性線維; 血管; 積層化; 酸素化

Vascular elastic fibers play a very important role in maintaining the structure of the arteries. The impairment of elastic fiber formation is closely related with aging and vascular diseases. We hypothesized that mecanical stresses onto the arteries would affect elastic fiber formation. Therefore, we tried to perform the quantitative analysis of the relation between elastic fiber formation and the types and strength of mechanical stresses. We found that elastic fiber formation was promoted in multi-layers of smooth muscle cells or by cycle stretch.

血管弹性纤维在维持动脉结构中起着非常重要的作用。弹性纤维形成障碍与衰老和血管疾病密切相关。我们假设动脉上的机械应力会影响弹性纤维的形成。因此，我们试图对弹性纤维的形成与机械应力的类型和强度之间的关系进行定量分析。我们发现，弹性纤维的形成促进了多层平滑肌细胞或周期拉伸。

项目成果

Nov is a novel protein secreted by prostaglandin E2 stimulation from the rat ductus arteriosus

Nov 是一种由大鼠动脉导管前列腺素 E2 刺激分泌的新型蛋白质

• 发表时间: 2011
• 作者: 岩井謙治;永澤和道;加藤尚志;南沢享
• 通讯作者: 南沢享

3D cellular muti-layer of rat smooth muscle cells has a potential as a novel ex vivo art erial model

大鼠平滑肌细胞的 3D 细胞多层具有作为新型离体动脉模型的潜力

• 发表时间: 2012
• 作者: 石渡遼;横山詩子;門脇功治;松崎典弥;明石満;石川義弘;南沢享
• 通讯作者: 南沢享

Cardiac-Specific Activation of Angiotensin II Type 1 Receptor–Associated Protein Completely Suppresses Cardiac Hypertrophy in Chronic Angiotensin II–Infused Mice

• DOI: 10.1161/hypertensionaha.109.147207
• 发表时间: 2010-05
• 期刊: Hypertension
• 影响因子: 8.3
• 作者: H. Wakui;K. Tamura;Yutaka Tanaka;M. Matsuda;Y. Bai;Toru Dejima;Shin-ichiro Masuda;Atsu-ichiro Shigenaga;Akinobu Maeda;M. Mogi;Naoaki Ichihara;Yusuke Kobayashi;N. Hirawa;T. Ishigami;Y. Toya;M. Yabana;M. Horiuchi;S. Minamisawa;S. Umemura

Prostaglandin EP4 Signaling Negatively Regulates Vascular Elastic Fiber Assembly.

前列腺素 EP4 信号传导对血管弹性纤维组装产生负调节。

• 发表时间: 2011
• 作者: Yokoyama U;Kato Y;Suzuki S;Masuda M;Asou T;Aoki H;Sugimoto Y;Nakamura T;Minamisawa S;Ishikawa Y
• 通讯作者: Ishikawa Y

Caveolin gene transfer improves glucose metabolism in diabetic mice

• DOI: 10.1152/ajpcell.00077.2009
• 发表时间: 2010-03-01
• 期刊: AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
• 影响因子: 5.5
• 作者: Otsu, Koji;Toya, Yoshiyuki;Ishikawa, Yoshihiro
• 通讯作者: Ishikawa, Yoshihiro