Analysis of evidence-practice gap using healthcare claims(receipts) database : with special reference to implementation of the recommendations in the clinical practice guidelines and adherence to the alert in package insert.

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In recent years, the problem of underuse of useful clinical evidence is coming to be important-evidence-practice gap. The major concern about evidence-practice gap is insufficient implementation of evidence-based effective treatment, however, the perspective can be extended to measures to improve drug safety and prevention of drug related adverse events. At first, this study characterized the database of receipt(healthcare claims) and the usefulness for research purpose. Afterwards, two cases(implementation of recommendation of preventive drug use against steroid-induced osteoporosis, adherence to the alert indicated in revised package insert for ergot-derived anti-Parkinson drugs, of which risk of valvulopathy has been identified) were examined using this database. Through these analyses, the receipt database was proved to be useful to study evidence-practice gap.