A Multi-Center Prospective Registration and Cohort Study on Prognosis and Predictors of Acute Myocardial Infarction in Japan.

日本急性心肌梗死的预后和预测因素的多中心前瞻性登记和队列研究。

• 批准号: 14207102
• 负责人: NAKAYAMA Takeo
• 金额: $ 20.22万
• 依托单位: KYOTO UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (A)
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2005
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14207102/
• 关键词: myocardial infarction; epidemiologic research; Quality of Life; medical economics; database; Quality of Life (QOL); Quality if Life(QOL)

The advances in the treatment techniques have contributed to improving prognosis of acute myocardial infarction (AMI), however, clinical evidence are limited in Asia including Japan about medical practice patterns as well as other factors influencing AMI prognosis and their effect on the actual health outcome. This study aims to examine the factors influencing prognosis with special reference to QOL after AMI, and to carry out an economic evaluation of the treatment outcome.This is a multi-center prospective cohort study. Subjects are 20-to-79 year-old patients with (first or recurrent) AMI who visit one of the university hospitals in collaboration as follows : Iwate Medical University, Kitasato University, Nippon Medical University, Tokyo Medical University, Osaka City University. An online registry system provided by the University Medical Information Network (UMIN) will be used to register those patients giving written consent and willing to participate in this study. An officially approved independent personal information center will be set up in order to guarantee privacy protection all along the follow-up survey. The main outcome measures are QOL evaluated by SF-36 and EQ5D six months after discharge from hospital. Records of the incidence of serious vascular events (such as recurrent coronary events and cerebrovascular accidents) as well as of deaths that result from such events occurring within a year of discharge will be filed.Finally, 331 cases (men : 289, women : 42) participated in this study for a period of two years and subsequently were followed up for one year after discharge from hospital. Within the follow up period, 7 cases readmitted the hospital and 6 cases died. Overall follow-up rate was over 80%. The database, which was developed for the cohort study, is available for the future analysis of predictors of clinical outcomes including subjective QOL. Multivariate analyses such as Cox regression analysis will be applied for the data set.

治疗技术的进步有助于改善急性心肌梗死（AMI）的预后，然而，在亚洲（包括日本），有关医疗实践模式以及影响AMI预后的其他因素及其对实际健康结果的影响的临床证据有限。本研究旨在探讨影响急性心肌梗死患者预后的因素，特别是生活质量，并对治疗结果进行经济学评价，这是一项多中心前瞻性队列研究。受试者为20-79岁的AMI（首次或复发）患者，他们在以下合作的大学医院就诊：岩手医科大学、北里大学、日本医科大学、东京医科大学、大坂市立大学。大学医学信息网络（UMIN）提供的在线登记系统将用于登记提供书面同意并愿意参加本研究的患者。为了在后续调查的沿着中保证隐私保护，将建立一个官方批准的独立个人信息中心。主要结局指标为出院后6个月用SF-36和EQ 5D评估的QOL。记录严重血管事件（如冠状动脉事件和脑血管意外）的发生率以及出院后一年内发生的此类事件导致的死亡。最终，331例（男性：289例，女性：42例）参加了为期两年的研究，并随后在出院后随访一年。随访期内再入院7例，死亡6例。总体随访率超过80%。该数据库是为队列研究开发的，可用于未来分析临床结局的预测因素，包括主观生活质量。将对数据集进行多变量分析，如考克斯回归分析。

项目成果

Factors affecting the blood concentration of ionized magnesium in patients in the acute phase of myocardial infarction.

心肌梗死急性期患者血离子镁浓度的影响因素

• 发表时间: 2004
• 期刊: Heart Vessels. Nov;19(6)
• 作者: Ueshima K;Tachibana H;Suzuki T;Hiramori K
• 通讯作者: Hiramori K

Fukuhara S, et al.: "Why has the use of health economic evaluation in Japan lagged behind that in other developed countries?"Pharmacoeconomics. 20. 1-7 (2002)

Fukuhara S, et al.：“为什么日本健康经济学评价的使用落后于其他发达国家？”药物经济学。

日本発のエビデンスを促進するために : ガイドラインヘの影響力を検証する.

推广源自日本的证据：检验其对指南的影响。

• 发表时间: 2005
• 期刊: EBMジャーナル 7
• 作者: 鈴木博道;中山健夫
• 通讯作者: 中山健夫

Evidence-based healthcare and health informatics: Derivations and extension of epidemiology

• DOI: 10.2188/jea.16.93
• 发表时间: 2006-05-01
• 期刊: JOURNAL OF EPIDEMIOLOGY
• 影响因子: 4.7
• 作者: Nakayama, Takeo

Long-term beneficial effect of infarct-related artery patency in acute anterior myocardial infarction in patients with poor myocardial viability in the region-at-risk.

梗死相关动脉通畅对高危区域心肌活力较差的急性前壁心肌梗死患者具有长期有益作用。

• 发表时间: 2004
• 期刊: Circ J. Dec;68(12)
• 作者: Fukuda D;Yoshiyama M;Shimada K;Kawarabayashi T;Tanaka A;Ehara S;Nakamura Y;Akioka K;Takeuchi K;Yoshikawa J
• 通讯作者: Yoshikawa J