The study to clarify a mechanism of replacing growth of the hepatocellular carcinoma using the adipose tissue derived stem cells
The study to clarify a mechanism of replacing growth of the hepatocellular carcinoma using the adipose tissue derived stem cells
批准号:
22659243
负责人:
SHIMADA Mitsuo
金额:
$2.11万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2011
中文摘要
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英文摘要
We investigated the role of the adipose tissue-derived stem cells(ADSC) in replacing growth of hepatoccellar carcinoma(HCC). HCC cell line(HuH7) and ADSC were co-cultured with or without cell-cell contact to clarify whether mediator affected HCC cell growth. And we concluded cell contact was important process in cell growth during co-culture HCC cells with ADSC. In addition, immunohistochemical staining of stemness marker(CD44 and CD133) and junction protein(Connexin 32) was performed in eleven well differentiated HCC patients with replacing growth. No positive cells were recognized in the invasive front area, however, junction protein(Cx32) was expressed at peripheral area in cytoplasm.
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ヒト脂肪由来幹細胞による肝再生療法に関する基礎的検討
利用人类脂肪干细胞进行肝脏再生治疗的基础研究
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[斉藤 裕, 他12名, 森根 裕二]
通讯作者:
森根 裕二
癌幹細胞のepigenetic修飾と癌根治療法への可能性
癌症干细胞的表观遗传修饰和根治性癌症治疗的潜力
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Sugiyama M., et al, 森根裕二]
通讯作者:
森根裕二
肝虚血再灌流傷害におけるヒト脂肪由来幹細胞ホーミング効果の機序解明
阐明人脂肪干细胞归巢效应在肝缺血再灌注损伤中的作用机制
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[斉藤 裕, 他11名, 森根 裕二]
通讯作者:
森根 裕二
The possibility of adipose-derived regenerative cells for an alternative therapy for liver failure
脂肪来源的再生细胞作为肝衰竭替代疗法的可能性
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Oki E., et al, Yu Saito, Hiroki Mori]
通讯作者:
Hiroki Mori
The possibility of adipose-derived stem cells for an alternative therapy for liver failure
脂肪干细胞作为肝衰竭替代疗法的可能性
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Ikeda T., et al, Yu Saito]
通讯作者:
Yu Saito
共 19 条
Development of integrated treatment for impaired liver regeneration on non-alcoholic steatohepatitis
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批准号:18H02871
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项目类别:Grant-in-Aid for Scientific Research (B)
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Development of multidisciplinary therapy for aged liver insufficiency based on the mechanism of hepatic stellate cell dysfunction.
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The possible mechanism on homing effect of adipose-derived stem cells to the injured liver
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批准号:24659611
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Development of multidisciplinary therapy based on mechanism of liver insufficiency in a use of Aged partial graft after liver transplantation.
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批准号:23390324
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$12.15万
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财政年份:2011
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负责人:SHIMADA Mitsuo
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依托单位:
脂肪肝グラフト部分肝移植における機能不全の解明と統合的治療法の開発
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批准号:20390359
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项目类别:Grant-in-Aid for Scientific Research (B)
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财政年份:2008
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负责人:SHIMADA Mitsuo
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依托单位:
The strategies for overcoming the graft dysfunction after liver transplantation using small-for-size graft
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批准号:17390370
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$10.05万
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财政年份:2005
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负责人:SHIMADA Mitsuo
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依托单位:
Promotion of liver regeneration and intrahepatic metastasis of hepatocellular carcinoma by Histone acetylation
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批准号:14370392
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.96万
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财政年份:2002
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负责人:SHIMADA Mitsuo
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依托单位:
Development of a super liver graft resistant to various kinds of injuries by a gene-transfer technique
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批准号:13357011
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$32.86万
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财政年份:2001
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负责人:SHIMADA Mitsuo
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依托单位: