脂肪肝グラフト部分肝移植における機能不全の解明と統合的治療法の開発

脂肪肝部分肝移植功能障碍的阐明及综合治疗方法的开发

• 批准号: 20390359
• 负责人: SHIMADA Mitsuo
• 金额: $ 12.65万
• 依托单位: The University of Tokushima
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20390359/
• 关键词: 肝不全; 肝移植; 脂肪肝; 肝虚血再灌流傷害; 虚血再潅流傷害; 大量肝切除術

The majority of liver transplantation in Japan is living donor liver transplantation. As proportion of metabolic syndrome has recently been increasing, fatty liver of a candidate of donor has become a problem. We developed an animal model of non-alcoholic fatty liver (NAFL) disease, and gave similar surgical insults as liver transplantation, including ischemia-reperfusion injury and massive hepatectomy in the NAFL model. We obtained several novel findings regarding the mechanisms, by which NAFL induced liver functional insufficiency. We also found some possible therapeutic agents and strategies, which may improve the liver dysfunction and may support liver regeneration in these animal models.

日本的肝移植大部分是活体肝移植。近年来，随着代谢综合征的比例不断增加，供体候选者的脂肪肝已成为一个问题。我们开发了非酒精性脂肪肝（NAFL）疾病的动物模型，并给予与肝移植类似的手术损伤，包括在NAFL模型中进行缺血再灌注损伤和大规模肝切除术。我们获得了关于 NAFL 引起肝功能不全的机制的一些新发现。我们还发现了一些可能的治疗药物和策略，可以改善这些动物模型中的肝功能障碍并支持肝再生。

项目成果

Geranylgeranylacetone prevents acute liver damage after massive hepatectomy in rats through suppression of a CXC chemokine GR01 and induction of heat shock proteins.

香叶基香叶基丙酮通过抑制 CXC 趋化因子 GR01 和诱导热休克蛋白来预防大鼠大规模肝切除术后的急性肝损伤。

• 发表时间: 2009
• 期刊: J Gastrointest Surg 13(1)
• 作者: Kanemura H;Shimada M
• 通讯作者: Shimada M

Effect of MHN-02 on ischemia-reperfusion injury in murine nonalcoholic fatty liver

MHN-02对小鼠非酒精性脂肪肝缺血再灌注损伤的影响

• 发表时间: 2008
• 作者: Nii A;et al.
• 通讯作者: et al.

高度進行肝癌に対する外科的アプローチミラノ基準外症例に対する肝移植

高度晚期肝癌的手术方法 米兰标准以外的病例进行肝移植

• 发表时间: 2009
• 期刊: 肝胆膵 59
• 作者: 島田光生;et al.
• 通讯作者: et al.

Beneficial use of the round ligament as a patch graft for vena cava reconstruction

• DOI: 10.1007/s00534-007-1319-1
• 发表时间: 2008-11-01
• 期刊: JOURNAL OF HEPATO-BILIARY-PANCREATIC SURGERY
• 作者: Ikegami, Toru;Shimada, Mitsuo;Hanaoka, Jun
• 通讯作者: Hanaoka, Jun

A simple formula to calculate the liver drainage volume of the accessory right hepatic vein using its diameter alone

• DOI: 10.1016/j.surg.2009.06.004
• 发表时间: 2009-08-01
• 期刊: SURGERY
• 影响因子: 3.8
• 作者: Hanaoka, Jun;Shimada, Mitsuo;Kanemura, Hirofumi
• 通讯作者: Kanemura, Hirofumi