脂肪肝グラフト部分肝移植における機能不全の解明と統合的治療法の開発

在日本，大多数肝移植是活体肝移植。近年来，随着代谢综合征的比例越来越高，候选供体的脂肪肝已成为一个问题。我们建立了非酒精性脂肪肝（NAFL）疾病的动物模型，并在NAFL模型中进行了与肝移植相似的手术损伤，包括缺血再灌注损伤和大面积肝切除术。我们获得了一些关于NAFL诱导肝功能不全的机制的新发现。我们还发现了一些可能的治疗药物和策略，这些药物和策略可能改善这些动物模型的肝功能障碍，并可能支持肝脏再生。

The majority of liver transplantation in Japan is living donor liver transplantation. As proportion of metabolic syndrome has recently been increasing, fatty liver of a candidate of donor has become a problem. We developed an animal model of non-alcoholic fatty liver (NAFL) disease, and gave similar surgical insults as liver transplantation, including ischemia-reperfusion injury and massive hepatectomy in the NAFL model. We obtained several novel findings regarding the mechanisms, by which NAFL induced liver functional insufficiency. We also found some possible therapeutic agents and strategies, which may improve the liver dysfunction and may support liver regeneration in these animal models.