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Development of multidisciplinary therapy based on mechanism of liver insufficiency in a use of Aged partial graft after liver transplantation.

Development of multidisciplinary therapy based on mechanism of liver insufficiency in a use of Aged partial graft after liver transplantation.
基于肝功能不全机制的多学科治疗在肝移植术后使用老年部分移植物中的发展。
批准号：
23390324
负责人：
SHIMADA Mitsuo
金额：
$12.15万
依托单位：
The University of Tokushima
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2011
资助国家：
日本
项目状态：
已结题
起止时间：
2011-04-01 至 2014-03-31
来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23390324/
关键词：
肝不全加齢肝幹細胞加齢遺伝子マイクロダイアライシス

项目摘要

项目成果

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相关文献

中文摘要
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英文摘要
The majority of liver transplantation in Japan is living donor liver transplantation. As aging population has recently been increasing, aged liver of a donor candidate has become a most problem. We gave similar surgical insults as liver transplantation, including ischemia-reperfusion injury and massive hepatectomy in the aged liver. We obtained several novel findings regarding the mechanisms, by which aging induced liver functional and regenerative insufficiency. We also found some possible therapeutic agents and strategies including ADRC, HDAC inhibitor and the others, which may improve the liver dysfunction and may support liver regeneration in these animal models.
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会议论文
The gene profile in the spleen under rat small-for-size graft model using cDNA microarray and pathway analaysis
使用 cDNA 微阵列和通路分析研究大鼠小型移植模型下脾脏的基因谱
DOI： --
发表时间： 2013
期刊：
影响因子： --
作者： [Arakawa Y , Shimada M, Ishikawa D, Y amada S, Saito Y , T akasu C, Iwahashi S, Kanamoto M, Mori H, Ikemoto T , Morine Y , Imura S, Utsunomiya T , Sato H, Miyake H]
通讯作者： Miyake H
Beneficial Effects of Follistatin in Hepatic Ischemia-Reperfusion Injuries in Rats
DOI： 10.1007/s10620-010-1401-4
发表时间： 2011-04-01
期刊： DIGESTIVE DISEASES AND SCIENCES
影响因子： 3.1
作者： [Kanamoto, Mami, Shimada, Mitsuo, Arakawa, Yusuke]
通讯作者： Arakawa, Yusuke
Impact of a new refrigerator for the preservation of whole blood.
新冰箱对保存全血的影响。
DOI： 10.1016/j.jss.2010.09.011
发表时间： 2012
期刊： The Journal of surgical research
影响因子： --
作者： [M. Kanamoto, M. Shimada, T. Utsunomiya, S. Imura, Y. Morine, T. Ikemoto, H. Mori, J. Hanaoka]
通讯作者： J. Hanaoka
Recovery pattern of non-protein respiratory quotient and non-esterified fatty acids after liver resection
肝切除术后非蛋白质呼吸商和非酯化脂肪酸的恢复模式
DOI： 10.1016/j.nut.2013.09.012
发表时间： 2014
期刊： Nutrition
影响因子： 4.4
作者： [Sugihara K, Yamanaka-Okumura H, Teramoto A, Urano E, Katayama T, Mori H, Utsunomiya T, Shimada M, Takeda E]
通讯作者： Takeda E
共 42 条
    Development of integrated treatment for impaired liver regeneration on non-alcoholic steatohepatitis
    • 批准号：
      18H02871
    • 项目类别：
      Grant-in-Aid for Scientific Research (B)
    • 资助金额：
      $11.07万
    • 财政年份：
      2018
    • 负责人：
      SHIMADA Mitsuo
    • 依托单位：
      The University of Tokushima
    Development of multidisciplinary therapy for aged liver insufficiency based on the mechanism of hepatic stellate cell dysfunction.
    • 批准号：
      26293288
    • 项目类别：
      Grant-in-Aid for Scientific Research (B)
    • 资助金额：
      $10.23万
    • 财政年份：
      2014
    • 负责人：
      SHIMADA Mitsuo
    • 依托单位：
      The University of Tokushima
    The possible mechanism on homing effect of adipose-derived stem cells to the injured liver
    • 批准号：
      24659611
    • 项目类别：
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额：
      $2.41万
    • 财政年份：
      2012
    • 负责人：
      SHIMADA Mitsuo
    • 依托单位：
      The University of Tokushima
    The study to clarify a mechanism of replacing growth of the hepatocellular carcinoma using the adipose tissue derived stem cells
    • 批准号：
      22659243
    • 项目类别：
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额：
      $2.11万
    • 财政年份：
      2010
    • 负责人：
      SHIMADA Mitsuo
    • 依托单位：
      The University of Tokushima