Roles of Glial Cells in the Action of Inhalation Anesthetics
Roles of Glial Cells in the Action of Inhalation Anesthetics
批准号:
22659282
负责人:
FUKUDA Kazuhiko
金额:
$2.04万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2011
中文摘要
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英文摘要
First, involvement of glial cells in the analgesic action of opioids was tested. Analysis of knockout mice and mutant mice revealed that tolerance to opioid analgesics is induced by microglial activation by a mechanism which does not involve the toll-like receptor 4. Next, it was demonstrated that hypoxia-or acute anemia-induced erythropoietin expression in the brain is inhibited by a volatile anesthetic, isoflurane. This phenomenon is suggested to be caused by inhibition of hypoxia-inducible factor 2 activity by isoflurane.
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DOI:
10.1371/journal.pone.0029378
发表时间:
2011
期刊:
PloS one
影响因子:
3.7
作者:
[Tanaka T, Kai S, Koyama T, Daijo H, Adachi T, Fukuda K, Hirota K]
通讯作者:
Hirota K
ヒト単核球における人工心肺後DNA損傷に対するシベレスタットの効果
西维来司他对体外循环后人单核细胞DNA损伤的影响
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[辻川洋, 石井久成, 福田和彦]
通讯作者:
福田和彦
モルヒネ耐性成立におけるミクログリア活性化にはtoll-like receptor 4は関与しない
Toll 样受体 4 不参与吗啡耐受期间小胶质细胞的激活
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[深川博志, 小山智弘, 福田和彦]
通讯作者:
福田和彦
タバコ煙抽出物はヒト肺胞II型上皮細胞株(A549)において低酸素誘導性因子1(hypoxia-inducible factor 1:HIF-1)を活性化する
烟草烟雾提取物激活人肺泡 II 型上皮细胞系 (A549) 中的缺氧诱导因子 1 (HIF-1)
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[大条紘樹, 鈴木堅固,岸本俊, 甲斐慎一, 広田喜一, 福田和彦]
通讯作者:
福田和彦
Augmented damage of islets by impaired exocrine acinar cells undergoing apoptosis that is possibly converted to necrosis during isolation.
受损的外分泌腺泡细胞发生凋亡,在分离过程中可能转化为坏死,从而加剧了胰岛的损伤。
DOI:
10.4161/isl.3.3.15611
发表时间:
2011
期刊:
Islets
影响因子:
2.2
作者:
[Elgendy H, 興津輝, 木村泰子, 劉喜宝, Nafady-Hego H, 倉田二郎, 寺前洋生, Elbahrawy A, 上 本 伸 二 , 福田和彦]
通讯作者:
福田和彦
Effects of anesthetics and opioids on the Wnt/bsta catenin pathway
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批准号:15K15571
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项目类别:Grant-in-Aid for Challenging Exploratory Research
-
资助金额:$2.16万
-
财政年份:2015
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负责人:FUKUDA Kazuhiko
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依托单位:
Roles of dynorphin and nociceptin in the analgesic action of anesthetics
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批准号:25670671
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.25万
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财政年份:2013
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负责人:FUKUDA Kazuhiko
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依托单位:
Avoiding delayed sleep phase in young children in extended day care.
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批准号:23530862
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.24万
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财政年份:2011
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负责人:FUKUDA Kazuhiko
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依托单位:
Evaluation of the Stress Responses Evoked by Surgical Stimuli or Pain and the Roles of Opioids in Their Control
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批准号:21249081
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$30.28万
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财政年份:2009
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负责人:FUKUDA Kazuhiko
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依托单位:
Routine daytime nap for preschool children : Is it beneficial or even harmful for them?
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批准号:18603001
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.71万
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财政年份:2006
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负责人:FUKUDA Kazuhiko
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依托单位:
Analysis and Clinical Application of Gene Expression Changes Induced by Perioperative Stresses
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批准号:16209046
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$31.78万
-
财政年份:2004
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负责人:FUKUDA Kazuhiko
-
依托单位:
Specifying the major factors, which induce the extreme delayed sleep and wake pattern frequently observed in Japanese people.
-
批准号:14510119
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.37万
-
财政年份:2002
-
负责人:FUKUDA Kazuhiko
-
依托单位:
Molecular Mechanisms for Modulation of Gene Expression by Anesthetics
-
批准号:13307046
-
项目类别:Grant-in-Aid for Scientific Research (A)
-
资助金额:$34.61万
-
财政年份:2001
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负责人:FUKUDA Kazuhiko
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依托单位:
Regulation of gene expression mediated by the opioid receptor and the nociceptin receptor
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批准号:11307028
-
项目类别:Grant-in-Aid for Scientific Research (A).
-
资助金额:$21.31万
-
财政年份:1999
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负责人:FUKUDA Kazuhiko
-
依托单位:
Longitudinal study on sleep and its problem through preschool and elementary school period
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批准号:10610095
-
项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.79万
-
财政年份:1998
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负责人:FUKUDA Kazuhiko
-
依托单位:
Molecular Biological Study of the Signal Transduction Mechanism of the G-Protein-Coupled Receptors Involved in Pain
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批准号:09307035
-
项目类别:Grant-in-Aid for Scientific Research (A)
-
资助金额:$22.53万
-
财政年份:1997
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负责人:FUKUDA Kazuhiko
-
依托单位:
Circadian rhythm of sleep and wakefulness : estimation of genetic influences with the method of twin study
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批准号:07610063
-
项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$0.96万
-
财政年份:1995
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负责人:FUKUDA Kazuhiko
-
依托单位:
海外基金