New Therapy for Retinoblastoma by Targeting Retinal Progenitor Cells

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Retinoblastoma is caused by deregulated proliferation of retinal progenitor cells, which normally differentiate into all types of retinal neurons and Muller glia. Therefore, it is expected that molecular mechanisms which regulate differentiation and proliferation of retinal progenitor cells can be novel targets to treat retinoblastoma. In this research program, we demonstrated that the nuclear receptor Tlx and the receptor tyrosine kinase VEGFR2 are co-expressed in retinal progenitor cells, and disruptions of these genes similarly resulted in abnormal development and impaired homeostasis of mouse retinal tissues.