The role of membrane nanotubes in the immune system

膜纳米管在免疫系统中的作用

• 批准号: 22689017
• 负责人: HASE Koji
• 金额: $ 15.97万
• 依托单位: The University of Tokyo (2012)The Institute of Physical and Chemical Research (2010-2011)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (A)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22689017/
• 关键词: 粘膜免疫; 細胞間情報伝達; 膜ナノチューブ; M-Sec; RalA; TNFaip2; Exocyst複合体; Exocyst complex; M細胞

Cell-to-cell communication is essential for the development and maintenance of multicellular organisms. The tunneling nanotube (TNT) is a recently recognized distinct type of intercellular communication device. We have recently shown that M-Sec (also called TNFaip2) is a key molecule for TNT formation. We also elucidated the molecular machinery of M-Sec-dependent TNT formation.

细胞间通讯对于多细胞生物的发育和维持至关重要。隧道纳米管（TNT）是一种最近被发现的独特类型的细胞间通讯装置。我们最近已经表明，M-Sec（也称为TNFaip 2）是TNT形成的关键分子。我们还阐明了M-Sec依赖的TNT形成的分子机制。

项目成果

Application of a Mouse Ligated Peyer's Patch Intestinal Loop Assay to Evaluate Bacterial Uptake by M cells

• DOI: 10.3791/3225
• 发表时间: 2011-12-01
• 期刊: JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
• 影响因子: 1.2
• 作者: Fukuda, Shinji;Hase, Koji;Ohno, Hiroshi
• 通讯作者: Ohno, Hiroshi

Specialized epithelial M cells contribute to immunosurveillance on the mucosal surface

专门的上皮 M 细胞有助于粘膜表面的免疫监视

• 发表时间: 2010
• 作者: Hiromi Onouchi;et al.;Hase K
• 通讯作者: Hase K

Antigen transcytosis by M cells : from molecular entities to biological significance

M细胞的抗原转胞吞作用：从分子实体到生物学意义

• 发表时间: 2010
• 作者: 柳原倫太郎;他;Hase K.
• 通讯作者: Hase K.

Intestinal microbiota shapes intestinal T cell balance via epigenetic modifications

肠道微生物群通过表观遗传修饰塑造肠道 T 细胞平衡

• 发表时间: 2012
• 作者: Chalise HN;Kai I;and Saito T;Hase K.
• 通讯作者: Hase K.

Specialized epithelial M cells contribute to immunosurveillance on the mucosal surface.

特殊的上皮 M 细胞有助于粘膜表面的免疫监视。

• 发表时间: 2010
• 作者: Takamasa Ishii;et al.;Hase K.
• 通讯作者: Hase K.